3EWX
K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Orotidine-5'-phosphate decarboxylase | polymer | 260 | 28317.8 | 1 | UniProt (P11172) Pfam (PF00215) | Homo sapiens | OMPdecase |
| 2 | B (A) | 6-HYDROXYURIDINE-5'-PHOSPHATE | non-polymer | 340.2 | 1 | Chemie (BMP) PubChem (46936519) PubChem (161647) PubChem (90874512) PubChem (3481674) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | D (A) | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Ala 222 | - | expression tag |
| Met 223 | - | expression tag |
| Ala 314 | Lys 314 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28317.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 432.3 | |
| All* | Total formula weight | 28750.0 |
