3MO7
Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP
Summary for 3MO7
Entry DOI | 10.2210/pdb3mo7/pdb |
Related | 2EAW 2P1F 3BGG 3BGJ 3BKO 3G3D |
Descriptor | Uridine 5'-monophosphate synthase, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total) |
Functional Keywords | ump synthase, orotidine 5'-monophosphate decarboxylase, 2'-fluoro-6-iodo-ump, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 30890.43 |
Authors | Liu, Y.,Kotra, L.P.,Pai, E.F. (deposition date: 2010-04-22, release date: 2011-04-06, Last modification date: 2023-09-06) |
Primary citation | Lewis, M.,Meza-Avina, M.E.,Wei, L.,Crandall, I.E.,Bello, A.M.,Poduch, E.,Liu, Y.,Paige, C.J.,Kain, K.C.,Pai, E.F.,Kotra, L.P. Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J.Med.Chem., 54:2891-2901, 2011 Cited by PubMed: 21417464DOI: 10.1021/jm101642g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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