3MO7

Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Uridine 5'-monophosphate synthase	polymer	279	30472.2	1	UniProt (P11172) Pfam (PF00215)	Homo sapiens (human)	UMP synthase, Orotate phosphoribosyltransferase, OPRTase, Orotidine 5'-phosphate decarboxylase, OMPdecase
2	B (A)	2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate)	non-polymer		326.2	1	Chemie (UFT)
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (A)	water	water		18.0	249	Chemie (HOH)

Sequence modifications

A: 34 - 291 (UniProt: P11172)

PDB	External Database	Details
Met 13	-	expression tag
Gly 14	-	expression tag
Ser 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
Ser 23	-	expression tag
Ser 24	-	expression tag
Gly 25	-	expression tag
Leu 26	-	expression tag
Val 27	-	expression tag
Pro 28	-	expression tag
Arg 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
His 32	-	expression tag
Met 33	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30472.2
Non-Polymers*	Number of molecules	2
	Total formula weight	418.3
All*	Total formula weight	30890.4

*Water molecules are not included.