4HKP
Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide
Summary for 4HKP
Entry DOI | 10.2210/pdb4hkp/pdb |
Related | 4HIB |
Descriptor | Uridine 5'-monophosphate synthase, GLYCEROL, 5-hydroxycytidine 5'-(dihydrogen phosphate), ... (5 entities in total) |
Functional Keywords | alpha-beta barrel, decarboxylase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69678.46 |
Authors | To, T.K.,Kotra, L.P.,Pai, E.F. (deposition date: 2012-10-15, release date: 2012-11-14, Last modification date: 2024-02-28) |
Primary citation | Purohit, M.K.,Poduch, E.,Wei, L.W.,Crandall, I.E.,To, T.,Kain, K.C.,Pai, E.F.,Kotra, L.P. Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J.Med.Chem., 55:9988-9997, 2012 Cited by PubMed: 22991951DOI: 10.1021/jm301176r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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