4HKP
Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | LYS53 |
| A | PHE118 |
| A | LEU119 |
| A | ASP149 |
| A | GOL302 |
| A | HOH435 |
| A | HOH504 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | GOL301 |
| A | HOH435 |
| A | SER146 |
| A | ARG174 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | LYS61 |
| A | PRO86 |
| A | GLU275 |
| A | ARG278 |
| A | HOH493 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TKW A 304 |
| Chain | Residue |
| A | SER68 |
| A | ASP70 |
| A | LYS92 |
| A | HIS94 |
| A | ASP123 |
| A | LYS125 |
| A | MET182 |
| A | SER183 |
| A | ILE212 |
| A | PRO228 |
| A | GLN241 |
| A | TYR243 |
| A | GLY261 |
| A | ARG262 |
| A | HOH413 |
| A | HOH414 |
| A | HOH415 |
| A | HOH462 |
| A | HOH468 |
| B | ASP128 |
| B | ILE129 |
| B | THR132 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 16B A 305 |
| Chain | Residue |
| A | SER68 |
| A | ASP70 |
| A | LYS92 |
| A | HIS94 |
| A | ASP123 |
| A | LYS125 |
| A | GLU181 |
| A | MET182 |
| A | SER183 |
| A | PRO228 |
| A | GLN241 |
| A | TYR243 |
| A | GLY261 |
| A | ARG262 |
| A | HOH413 |
| A | HOH414 |
| A | HOH415 |
| A | HOH502 |
| B | ASP128 |
| B | ILE129 |
| B | THR132 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 301 |
| Chain | Residue |
| B | LYS53 |
| B | ALA113 |
| B | LYS114 |
| B | PHE118 |
| B | LEU119 |
| B | ASP149 |
| B | HOH522 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| B | LEU232 |
| B | ALA234 |
| B | HOH458 |
| B | HOH512 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| B | SER37 |
| B | GLN59 |
| B | TYR285 |
| B | LEU286 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TKW B 304 |
| Chain | Residue |
| A | ASP128 |
| A | ILE129 |
| A | THR132 |
| B | SER68 |
| B | ASP70 |
| B | LYS92 |
| B | HIS94 |
| B | LYS125 |
| B | MET182 |
| B | SER183 |
| B | ILE212 |
| B | PRO228 |
| B | GLN231 |
| B | GLN241 |
| B | TYR243 |
| B | GLY261 |
| B | ARG262 |
| B | HOH401 |
| B | HOH404 |
| B | HOH420 |
| B | HOH421 |
| B | HOH482 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV |
| Chain | Residue | Details |
| A | ILE120-VAL133 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
