2QCM

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP

Summary for 2QCM

Entry DOI	10.2210/pdb2qcm/pdb
Related	2jgy 2v30
Descriptor	Uridine 5'-monophosphate synthase (UMP synthase), 6-(HYDROXYMETHYL)URIDINE 5'-(DIHYDROGEN PHOSPHATE) (3 entities in total)
Functional Keywords	ump synthase, decarboxylase, catalytic proficiency, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28685.03
Authors	Wittmann, J.,Rudolph, M. (deposition date: 2007-06-19, release date: 2007-11-06, Last modification date: 2021-10-20)
Primary citation	Wittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure, 16:82-92, 2008 Cited by PubMed: 18184586 DOI: 10.1016/j.str.2007.10.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation