2QCM

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE JW5 A 482

Chain	Residue
A	SER257
A	MET371
A	SER372
A	ILE401
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH488
A	HOH494
A	ASP259
A	HOH530
A	LYS281
A	HIS283
A	ASN312
A	ASP317
A	ILE318
A	THR321
A	ASN341

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS314
A	ASN312

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS281
A	ASP317
A	LYS314
A	ASN312

---