2QCM
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Uridine 5'-monophosphate synthase (UMP synthase) | polymer | 260 | 28330.8 | 1 | UniProt (P11172) Pfam (PF00215) | Homo sapiens (human) | |
| 2 | B (A) | 6-(HYDROXYMETHYL)URIDINE 5'-(DIHYDROGEN PHOSPHATE) | non-polymer | 354.2 | 1 | Chemie (JW5) | |||
| 3 | C (A) | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Ala 222 | - | expression tag |
| Met 223 | - | expression tag |
| Asn 312 | Asp 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28330.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 354.2 | |
| All* | Total formula weight | 28685.0 |
