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PDB: 429 件
8B0X
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BU of 8b0x by Molmil
Translating 70S ribosome in the unrotated state (P and E, tRNAs)
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Fromm, S.A, O'Connor, K.M, Purdy, M, Bhatt, P.R, Loughran, G, Atkins, J.F, Jomaa, A, Mattei, S.
登録日2022-09-08
公開日2022-11-30
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (1.55 Å)
主引用文献The translating bacterial ribosome at 1.55 angstrom resolution generated by cryo-EM imaging services.
Nat Commun, 14, 2023
8CGK
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Lincomycin and Avilamycin bound to the 50S subunit
分子名称: (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ...
著者Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N.
登録日2023-02-05
公開日2023-07-19
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.64 Å)
主引用文献Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
8CGV
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BU of 8cgv by Molmil
Tiamulin bound to the 50S subunit
分子名称: 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ...
著者Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N.
登録日2023-02-06
公開日2023-08-02
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.66 Å)
主引用文献Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
8CEU
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BU of 8ceu by Molmil
Retapamulin and Capreomycin bound to the 50S subunit
分子名称: 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ...
著者Paternoga, H, Beckert, B, Wilson, D.N.
登録日2023-02-02
公開日2023-07-26
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.83 Å)
主引用文献Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
8FTO
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BU of 8fto by Molmil
E. coli 70S ribosome with an improved MS2 tag inserted in H98
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Nissley, A.J, Cate, J.H.D.
登録日2023-01-12
公開日2023-08-02
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.85 Å)
主引用文献Interactions between terminal ribosomal RNA helices stabilize the E. coli large ribosomal subunit.
Rna, 29, 2023
8CAM
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BU of 8cam by Molmil
Evernimicin bound to the 50S subunit
分子名称: 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ...
著者Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N.
登録日2023-01-24
公開日2023-07-26
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.86 Å)
主引用文献Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
8E30
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BU of 8e30 by Molmil
E. coli 50S ribosome bound to compound streptogramin A analog 3142
分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
著者Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
登録日2022-08-16
公開日2023-06-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (1.91 Å)
主引用文献Potential for clicked streptogramin analogs
To Be Published
8AYE
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BU of 8aye by Molmil
E. coli 70S ribosome bound to thermorubin and fMet-tRNA
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Sanyal, S, Parajuli, N.P, Emmerich, A.G.
登録日2022-09-02
公開日2023-03-01
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (1.96 Å)
主引用文献Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria.
Nat Commun, 14, 2023
7K00
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BU of 7k00 by Molmil
Structure of the Bacterial Ribosome at 2 Angstrom Resolution
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Watson, Z.L, Ward, F.R, Meheust, R, Ad, O, Schepartz, A, Banfield, J.F, Cate, J.H.D.
登録日2020-09-02
公開日2020-09-23
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.98 Å)
主引用文献Structure of the bacterial ribosome at 2 angstrom resolution.
Elife, 9, 2020
8CGD
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BU of 8cgd by Molmil
Clindamycin bound to the 50S subunit
分子名称: 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ...
著者Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N.
登録日2023-02-03
公開日2023-07-26
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (1.98 Å)
主引用文献Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
8E3O
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BU of 8e3o by Molmil
E. coli 50S ribosome bound to solithromycin and VM1
分子名称: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 23S ribosomal RNA, 50S ribosomal protein L13, ...
著者Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
登録日2022-08-17
公開日2023-06-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (1.99 Å)
主引用文献Solithromycin siderophore conjugates
To Be Published
8QOA
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BU of 8qoa by Molmil
Structure of SecM-stalled Escherichia coli 70S ribosome
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ...
著者Gersteuer, F, Morici, M, Wilson, D.N.
登録日2023-09-28
公開日2024-03-20
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome.
Nat Commun, 15, 2024
8G6W
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BU of 8g6w by Molmil
Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe
分子名称: 16S rRNA, 2-AMINO-BENZAMIDE, 23S rRNA, ...
著者Majumdar, C, Cate, J.H.D.
登録日2023-02-16
公開日2023-04-05
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.02 Å)
主引用文献Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8BIM
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BU of 8bim by Molmil
Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site
分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ...
著者Koziej, L, Glatt, S.
登録日2022-11-02
公開日2023-08-16
実験手法ELECTRON MICROSCOPY (2.04 Å)
主引用文献Modulation of translational decoding by m 6 A modification of mRNA.
Nat Commun, 14, 2023
8BIL
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BU of 8bil by Molmil
Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.
分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ...
著者Koziej, L, Glatt, S.
登録日2022-11-02
公開日2023-08-16
実験手法ELECTRON MICROSCOPY (2.04 Å)
主引用文献Modulation of translational decoding by m 6 A modification of mRNA.
Nat Commun, 14, 2023
8E49
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BU of 8e49 by Molmil
E. coli 50S ribosome bound to antibiotic analog SLC31
分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
著者Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
登録日2022-08-17
公開日2023-06-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.05 Å)
主引用文献SLC collection of antibiotic analogs
To Be Published
8G6Y
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BU of 8g6y by Molmil
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe
分子名称: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminopyridine-4-carboxamide, ...
著者Majumdar, C, Cate, J.H.D.
登録日2023-02-16
公開日2023-04-05
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.09 Å)
主引用文献Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8E43
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E. coli 50S ribosome bound to compound streptogramin A analog 3336
分子名称: (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-4-(prop-2-en-1-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ...
著者Pellegrino, J, Lee, D.J, Seiple, I.B, Fraser, J.S.
登録日2022-08-17
公開日2023-06-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.09 Å)
主引用文献Streptogramin A analogs
To Be Published
7QQ3
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BU of 7qq3 by Molmil
Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A.
分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
著者Koller, T.O, Beckert, B, Wilson, D.N.
登録日2022-01-06
公開日2023-01-18
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
J.Am.Chem.Soc., 145, 2023
6XZ7
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BU of 6xz7 by Molmil
E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).
分子名称: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
著者Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L.
登録日2020-02-03
公開日2020-07-22
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.
Rna, 26, 2020
4YBB
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BU of 4ybb by Molmil
High-resolution structure of the Escherichia coli ribosome
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ...
著者Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D.
登録日2015-02-18
公開日2015-03-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High-resolution structure of the Escherichia coli ribosome.
Nat.Struct.Mol.Biol., 22, 2015
8ANA
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BU of 8ana by Molmil
Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit
分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ...
著者Koller, T.O, Morici, M, Wilson, D.N.
登録日2022-08-05
公開日2023-03-08
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Structural basis for translation inhibition by the glycosylated drosocin peptide.
Nat.Chem.Biol., 19, 2023
8EMM
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BU of 8emm by Molmil
Composite 70S ribosome structure for "Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Watson, Z.L, Cate, J.H.D.
登録日2022-09-28
公開日2023-05-31
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates.
Nat.Chem., 15, 2023
8BGE
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BU of 8bge by Molmil
Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation
分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ...
著者Koziej, L, Glatt, S.
登録日2022-10-27
公開日2023-08-16
実験手法ELECTRON MICROSCOPY (2.11 Å)
主引用文献Modulation of translational decoding by m 6 A modification of mRNA.
Nat Commun, 14, 2023
8E41
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BU of 8e41 by Molmil
E. coli 50S ribosome bound to tiamulin and VS1
分子名称: 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
著者Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
登録日2022-08-17
公開日2023-06-28
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.13 Å)
主引用文献Tiamulin and NPET binders
To Be Published

221371

件を2024-06-19に公開中

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