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PDB: 96 件
3FJI
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Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor
分子名称: Heparin-binding growth factor 1, SULFATE ION
著者Blaber, M, Lee, J.
登録日2008-12-14
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3CU1
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Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex
分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Fibroblast growth factor receptor 2, Heparin-binding growth factor 1
著者Guo, F, Dakshinamurthy, R, Thallapuranam, S.K.K, Sakon, J.
登録日2008-04-15
公開日2009-04-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of 2:2:2 FGFR2D2:FGF1:SOS complex
To be Published
1Z4S
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Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor
分子名称: Heparin-binding growth factor 1, SULFATE ION
著者Lee, J, Blaber, M.
登録日2005-03-16
公開日2006-02-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function.
Proteins, 62, 2005
3OJV
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Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1
著者Beenken, A, Mohammadi, M.
登録日2010-08-23
公開日2011-12-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3UD7
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Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes
分子名称: 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, PHOSPHATE ION
著者Hung, S.-C, Shi, Z.
登録日2011-10-27
公開日2012-11-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction
J.Am.Chem.Soc., 134, 2012
1EVT
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CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
分子名称: PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
著者Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
登録日2000-04-20
公開日2000-05-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1E0O
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CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ...
著者Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L.
登録日2000-04-03
公開日2000-10-23
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin
Nature, 407, 2000
1AXM
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HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
著者DiGabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
登録日1997-10-16
公開日1998-04-22
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
2AXM
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HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
著者Digabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
登録日1997-10-20
公開日1998-04-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
1RY7
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Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
分子名称: Fibroblast growth factor receptor 3, Heparin-binding growth factor 1
著者Olsen, S.K, Ibrahimi, O.A, Raucci, A, Zhang, F, Eliseenkova, A.V, Yayon, A, Basilico, C, Linhardt, R.J, Schlessinger, J, Mohammadi, M.
登録日2003-12-19
公開日2004-02-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proc.Natl.Acad.Sci.Usa, 101, 2004
4J23
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Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
分子名称: Fibroblast growth factor 1, Fibroblast growth factor receptor 2
著者Kudlinzki, D, Saxena, K, Sreeramulu, S, Schieborr, U, Dreyer, M, Schreuder, H, Schwalbe, H.
登録日2013-02-04
公開日2014-02-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.882 Å)
主引用文献Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer Cell, 23, 2013
2K43
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Acidic fibroblast growth factor solution structure in the FGF-1-C2A binary complex: key component in the fibroblast growthfactor non-classical pathway
分子名称: Heparin-binding growth factor 1
著者Mohan, S.K, Yu, C.
登録日2008-05-28
公開日2009-06-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献FGF-1-C2A binary complex structure: key component in the acidic fibroblast growth factor release
To be Published
2K4A
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FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway
分子名称: Heparin-binding growth factor 1, Synaptotagmin-1
著者Yu, C, Mohan, S.K.
登録日2008-06-02
公開日2009-06-09
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献FGF-1-C2A binary complex structure: key component in the acidic fibroblast growth factor release
To be Published
2RQ9
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Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new
分子名称: Heparin-binding growth factor 1
著者Enomoto, M, Xiang, L, Ishii, T, Tochio, N, Hosoda, K, Inoue, Y, Nameki, N, Wakamatsu, K.
登録日2009-03-12
公開日2010-03-16
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new
To be Published
1DZC
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BU of 1dzc by Molmil
High resolution structure of acidic fibroblast growth factor. Mutant FGF-4-ALA-(24-154), 24 NMR structures
分子名称: FIBROBLAST GROWTH FACTOR 1
著者Lozano, R.M, Pineda-Lucena, A, Gonzalez, C, Jimenez, M.A, Cuevas, P, Redondo-Horcajo, M, Sanz, J.M, Rico, M, Gimenez-Gallego, G.
登録日2000-02-24
公開日2000-03-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献1H-NMR Structural Characterization of a Non Mitogenic, Vasodilatory, Ischemia-Protector and Neuromodulatory Acidic Fibroblast Growth Factor
Biochemistry, 39, 2000
1DZD
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High resolution structure of acidic fibroblast growth factor (27-154), 24 NMR structures
分子名称: ACIDIC FIBROBLAST GROWTH FACTOR
著者Lozano, R.M, Pineda-Lucena, A, Gonzalez, C, Jimenez, M.A, Cuevas, P, Redondo-Horcajo, M, Sanz, J.M, Rico, M, Gimenez-Gallego, G.
登録日2000-02-24
公開日2000-03-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献1H-NMR Structural Characterization of a Non Mitogenic, Vasodilatory, Ischemia-Protector and Neuromodulatory Acidic Fibroblast Growth Factor
Biochemistry, 39, 2000
2KI4
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FGF1-S100A13 complex structure: key component in non-classical path way of FGF1
分子名称: Heparin-binding growth factor 1, Protein S100-A13
著者Krishna, S.M, Rani, S.G, Yu, C.
登録日2009-04-27
公開日2010-03-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.
J.Biol.Chem., 285, 2010
2K8R
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Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)
分子名称: Heparin-binding growth factor 1, INOSITOL HEXAKISPHOSPHATE
著者Kumar, S.M, Mohan, S.K, Chin, Y.
登録日2008-09-22
公開日2009-10-13
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)
To be Published
1RML
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NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES
分子名称: ACIDIC FIBROBLAST GROWTH FACTOR, NAPHTHALENE TRISULFONATE
著者Lozano, R.M, Jimenez, M.A, Santoro, J, Rico, M, Gimenez-Gallego, G.
登録日1998-05-21
公開日1998-11-11
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.
J.Mol.Biol., 281, 1998
2KI6
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The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion
分子名称: Heparin-binding growth factor 1, Protein S100-A13, Synaptotagmin-1
著者Krishna, S.M, Rani, S.G, Yu, C.
登録日2009-04-28
公開日2010-03-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.
J.Biol.Chem., 285, 2010
2ERM
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Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue
分子名称: 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, ISOPROPYL ALCOHOL
著者Canales, A, Lozano, R, Nieto, P.M, Martin-Lomas, M, Gimenez-Gallego, G, Jimenez-Barbero, J.
登録日2005-10-25
公開日2006-10-03
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.
Febs J., 273, 2006
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