4J23

Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex

Summary for 4J23

Entry DOI	10.2210/pdb4j23/pdb
Descriptor	Fibroblast growth factor receptor 2, Fibroblast growth factor 1 (2 entities in total)
Functional Keywords	protein-protein complex, immunoglobulin c-2 type, receptor domain, fgf binding, transferase, protein binding, membrane protein, signaling protein, signaling protein-transferase complex, signaling protein/transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	40630.00
Authors	Kudlinzki, D.,Saxena, K.,Sreeramulu, S.,Schieborr, U.,Dreyer, M.,Schreuder, H.,Schwalbe, H. (deposition date: 2013-02-04, release date: 2014-02-19, Last modification date: 2023-09-20)
Primary citation	Herbert, C.,Schieborr, U.,Saxena, K.,Juraszek, J.,De Smet, F.,Alcouffe, C.,Bianciotto, M.,Saladino, G.,Sibrac, D.,Kudlinzki, D.,Sreeramulu, S.,Brown, A.,Rigon, P.,Herault, J.P.,Lassalle, G.,Blundell, T.L.,Rousseau, F.,Gils, A.,Schymkowitz, J.,Tompa, P.,Herbert, J.M.,Carmeliet, P.,Gervasio, F.L.,Schwalbe, H.,Bono, F. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell, 23:489-501, 2013 Cited by PubMed: 23597563 DOI: 10.1016/j.ccr.2013.02.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.882 Å)

Structure validation