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PDB: 224 件
8BFA
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Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure
分子名称: Amyloid-beta precursor protein
著者Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
登録日2022-10-24
公開日2023-05-31
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
8OL2
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Murine type II Abeta fibril from APP23 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OL7
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MurineArc type I Abeta fibril from tg-APPArcSwe mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8KF4
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BU of 8kf4 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
分子名称: Amyloid-beta precursor protein
著者Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
登録日2023-08-15
公開日2024-08-21
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
To Be Published
7WVY
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BU of 7wvy by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
分子名称: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
8FF3
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Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B)
分子名称: Amyloid-beta precursor protein
著者Crooks, E.J, Fu, Z, Chowdury, S, Smith, S.O.
登録日2022-12-07
公開日2023-12-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献An electrostatic cluster guides A beta 40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy.
J.Struct.Biol., 216, 2024
8I4O
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BU of 8i4o by Molmil
Design of a split green fluorescent protein for sensing and tracking an beta-amyloid
分子名称: Beta-amyloid, Split Green flourescent protein
著者Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K.
登録日2023-01-20
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State.
Jacs Au, 3, 2023
7F29
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Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)
分子名称: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose
著者Xia, W.C, Sun, Y.P, Liu, C.
登録日2021-06-10
公開日2022-07-13
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation
J.Am.Chem.Soc., 143, 2021
8SEJ
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Type I beta-amyloid 42 Filaments from Down syndrome
分子名称: Amyloid-beta protein 42
著者Hoq, M.R, Bharath, S.R, Vago, F.S, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
3NYJ
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BU of 3nyj by Molmil
Crystal Structure Analysis of APP E2 domain
分子名称: Amyloid beta A4 protein, OSMIUM ION
著者Ha, Y, Hu, J, Lee, S, Liu, X.
登録日2010-07-15
公開日2011-06-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.
Biochemistry, 50, 2011
8BFB
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Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)
分子名称: Amyloid-beta precursor protein
著者Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
登録日2022-10-24
公開日2023-05-31
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
8OVM
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BU of 8ovm by Molmil
Lipidic amyloid-beta(1-40) fibril - polymorph L2
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-26
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
8OWD
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BU of 8owd by Molmil
Lipidic amyloid-beta(1-40) fibril - polymorph L3
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-27
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
9CZP
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BU of 9czp by Molmil
Type Id amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques
分子名称: Amyloid-beta protein 42
著者Hoq, M.R, Vago, F.S, Ozcan, K.A, Bharath, S.R.
登録日2024-08-05
公開日2024-10-02
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures of cotton wool plaques' amyloid beta and of tau filaments in dominantly inherited Alzheimer disease.
Acta Neuropathol, 148, 2024
8OTF
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BU of 8otf by Molmil
Ab typeII filament from Guam ALS/PDC
分子名称: Amyloid-beta precursor protein
著者Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
登録日2023-04-20
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
3SV1
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BU of 3sv1 by Molmil
Crystal structure of APP peptide bound rat Mint2 PARM
分子名称: Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein
著者Shen, Y, Long, J, Yan, X, Xie, X.
登録日2011-07-12
公開日2012-07-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
6XOV
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BU of 6xov by Molmil
CryoEM structure of human presequence protease in partial closed state 1
分子名称: Amyloid-beta precursor protein, Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
8OLN
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BU of 8oln by Molmil
DI1 Abeta fibril from tg-SwDI mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8KF1
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BU of 8kf1 by Molmil
The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
分子名称: 4-[2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethyl]-~{N}-methyl-aniline, P3(40)
著者Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
登録日2023-08-15
公開日2024-08-21
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
To Be Published
8KEW
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BU of 8kew by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril.
分子名称: P3(40)
著者Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
登録日2023-08-13
公開日2024-08-14
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
7O1Q
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BU of 7o1q by Molmil
Amyloid beta oligomer displayed on the alpha hemolysin scaffold
分子名称: Alpha-hemolysin hybridized Abeta
著者Wu, J, Blum, T.B, Farrell, D.P, DiMaio, F, Abrahams, J.P, Luo, J.
登録日2021-03-30
公開日2021-04-14
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold.
Angew.Chem.Int.Ed.Engl., 60, 2021
8OL5
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BU of 8ol5 by Molmil
Murine type II Abeta fibril from ARTE10 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8KF5
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BU of 8kf5 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
分子名称: Amyloid-beta precursor protein
著者Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
登録日2023-08-15
公開日2024-08-21
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
To Be Published
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
分子名称: Type IIIb beta-amyloid 40 Filament
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8OL3
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BU of 8ol3 by Molmil
Murine type III Abeta fibril from APP/PS1 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023

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件を2024-10-16に公開中

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