5FX6
 
 | | Novel inhibitors of human rhinovirus 3C protease | | 分子名称: | RHINOVIRUS 3C PROTEASE, ethyl (4R)-4-[[(2S,4S)-1-[(2S)-3-methyl-2-[(5-methyl-1,2-oxazol-3-yl)carbonylamino]butanoyl]-4-phenyl-pyrrolidin-2-yl]carbonylamino]-5-[(3S)-2-oxidanylidenepyrrolidin-3-yl]pentanoate | | 著者 | Kawatkar, S, Ek, M, Hoesch, V, Gagnon, M, Nilsson, E, Lister, T, Olsson, L, Patel, J, Yu, Q. | | 登録日 | 2016-02-24 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease.
Bioorg.Med.Chem.Lett., 26, 2016
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5FX5
 | | Novel inhibitors of human rhinovirus 3C protease | | 分子名称: | GLYCEROL, RHINOVIRUS 3C PROTEASE, TETRAETHYLENE GLYCOL, ... | | 著者 | Kawatkar, S, Ek, M, Hoesch, V, Gagnon, M, Nilsson, E, Lister, T, Olsson, L, Patel, J, Yu, Q. | | 登録日 | 2016-02-24 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease.
Bioorg.Med.Chem.Lett., 26, 2016
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6FFN
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1CQQ
 | | TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR | | 分子名称: | 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, TYPE 2 RHINOVIRUS 3C PROTEASE | | 著者 | Matthews, D, Ferre, R.A. | | 登録日 | 1999-08-10 | | 公開日 | 1999-09-20 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proc.Natl.Acad.Sci.USA, 96, 1999
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6FFS
 | | Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors | | 分子名称: | 3C Protease, SULFATE ION, ~{N}-[(2~{S},5~{S},14~{S})-2-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-9-methyl-3,8,15-tris(oxidanylidene)-1,4,9-triazacyclopentadec-14-yl]-5-methyl-1,2-oxazole-3-carboxamide | | 著者 | Wiesmann, C, Farady, C. | | 登録日 | 2018-01-09 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
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2HRV
 | | 2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2 | | 分子名称: | 2A CYSTEINE PROTEINASE, ZINC ION | | 著者 | Petersen, J.F.W, Cherney, M.M, Liebig, H.-D, Skern, T, Kuechler, E, James, M.N.G. | | 登録日 | 1999-04-29 | | 公開日 | 2000-05-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
EMBO J., 18, 1999
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1A3R
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7ARA
 | | Rhinovirus A2 2A protease in complex with zVAM.fmk | | 分子名称: | (phenylmethyl) ~{N}-[(2~{R})-3-methyl-1-[[(2~{S})-1-[[(3~{S})-1-methylsulfanyl-4-oxidanylidene-pentan-3-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]carbamate, (phenylmethyl) ~{N}-[(2~{S})-3-methyl-1-[[(2~{R})-1-[[(3~{R})-1-methylsulfanyl-4-oxidanylidene-pentan-3-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]carbamate, 2A protease, ... | | 著者 | Deutschmann-Olek, K.M, Skern, T, Bezerra, G.A, Yue, W.W. | | 登録日 | 2020-10-23 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.243 Å) | | 主引用文献 | Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk.
Virology, 562, 2021
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2XYA
 | | Non-covalent inhibtors of rhinovirus 3C protease. | | 分子名称: | 2-PHENYLQUINOLIN-4-OL, PICORNAIN 3C | | 著者 | Petersen, J, Edman, K, Edfeldt, F, Johansson, C. | | 登録日 | 2010-11-16 | | 公開日 | 2011-04-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Non-Covalent Inhibitors of Rhinovirus 3C Protease.
Bioorg.Med.Chem.Lett., 21, 2011
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1FPN
 | | HUMAN RHINOVIRUS SEROTYPE 2 (HRV2) | | 分子名称: | COAT PROTEIN VP1, COAT PROTEIN VP2, COAT PROTEIN VP3, ... | | 著者 | Verdaguer, N, Blaas, D, Fita, I. | | 登録日 | 2000-08-31 | | 公開日 | 2000-09-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of human rhinovirus serotype 2 (HRV2).
J.Mol.Biol., 300, 2000
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3TN9
 | | X-ray structure of the HRV2 empty capsid (B-particle) | | 分子名称: | Protein VP1, Protein VP2, Protein VP3 | | 著者 | Garriga, D, Pickl-Herk, A, Luque, D, Wruss, J, Caston, J.R, Blaas, D, Verdaguer, N. | | 登録日 | 2011-09-01 | | 公開日 | 2012-03-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid.
Plos Pathog., 8, 2012
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3VDD
 | | Structure of HRV2 capsid complexed with antiviral compound BTA798 | | 分子名称: | 3-ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzoxazole, Protein VP1, Protein VP2, ... | | 著者 | Morton, C.J, Feil, S.C, Parker, M.W. | | 登録日 | 2012-01-05 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
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3DPR
 | | Human rhinovirus 2 bound to a concatamer of the VLDL receptor module V3 | | 分子名称: | CALCIUM ION, LAURIC ACID, LDL-receptor class A 3, ... | | 著者 | Querol-Audi, J, Pous, J, Fita, I, Verdaguer, N. | | 登録日 | 2008-07-09 | | 公開日 | 2009-04-07 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Minor group human rhinovirus-receptor interactions: geometry of multimodular attachment and basis of recognition
Febs Lett., 583, 2009
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1V9U
 | | Human Rhinovirus 2 bound to a fragment of its cellular receptor protein | | 分子名称: | CALCIUM ION, Coat protein VP1, Coat protein VP2, ... | | 著者 | Verdaguer, N, Fita, I, Reithmayer, M, Moser, R, Blaas, D. | | 登録日 | 2004-02-03 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein
NAT.STRUCT.MOL.BIOL., 11, 2004
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8AY4
 | | Human rhinovirus 2 virion in situ | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | 著者 | Ishemgulova, A, Mukhamedova, L, Trebichalska, Z, Payne, P, Smerdova, L, Moravcova, J, Hrebik, D, Buchta, D, Skubnik, K, Fuzik, T, Novacek, J, Plevka, P. | | 登録日 | 2022-09-01 | | 公開日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Endosome rupture enables enteroviruses to infect cells.
To Be Published
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4L3B
 | | X-ray structure of the HRV2 A particle uncoating intermediate | | 分子名称: | Protein VP1, Protein VP2, Protein VP3 | | 著者 | Vives-Adrian, L, Querol-Audi, J, Garriga, D, Pous, J, Verdaguer, N. | | 登録日 | 2013-06-05 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (6.5 Å) | | 主引用文献 | Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle.
Proc.Natl.Acad.Sci.USA, 110, 2013
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8AY5
 | | Human rhinovirus 2 empty particle in situ | | 分子名称: | Capsid protein VP1, Capsid protein VP2, VP3 | | 著者 | Ishemgulova, A, Mukhamedova, L, Trebichalska, Z, Payne, P, Smerdova, L, Moravcova, J, Hrebik, D, Buchta, D, Skubnik, K, Fuzik, T, Novacek, J, Plevka, P. | | 登録日 | 2022-09-01 | | 公開日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | Endosome rupture enables enteroviruses to infect cells.
To Be Published
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