7ARA

Rhinovirus A2 2A protease in complex with zVAM.fmk

Summary for 7ARA

• Entry DOI: 10.2210/pdb7ara/pdb
• Descriptor: 2A protease, (phenylmethyl) ~{N}-[(2~{R})-3-methyl-1-[[(2~{S})-1-[[(3~{S})-1-methylsulfanyl-4-oxidanylidene-pentan-3-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]carbamate, ZINC ION, ... (5 entities in total)
• Functional Keywords: chymotrypsin-like cysteine protease, rhinoviral 2a protease, zvam.fmk, viral protein
• Biological source: Human rhinovirus 2 (HRV-2)
• Total number of polymer chains: 2
• Total formula weight: 33486.31

Authors

Deutschmann-Olek, K.M.,Skern, T.,Bezerra, G.A.,Yue, W.W. (deposition date: 2020-10-23, release date: 2021-07-28, Last modification date: 2024-01-31)

• Primary citation: Deutschmann-Olek, K.M.,Yue, W.W.,Bezerra, G.A.,Skern, T.; Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk.; Virology, 562:128-141, 2021; PubMed: 34315103; DOI: 10.1016/j.virol.2021.07.008

Experimental method

X-RAY DIFFRACTION (2.243 Å)