4L3B

X-ray structure of the HRV2 A particle uncoating intermediate

Summary for 4L3B

Related3TN9 1FPN
DescriptorProtein VP1, Protein VP2, Protein VP3 (3 entities in total)
Functional Keywordshrv2 capsid, virus
Biological sourceHuman rhinovirus A2 (HRV-2)
Cellular locationCapsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side  P04936 P04936 P04936
Total number of polymer chains3
Total molecular weight88042.18
Authors
Vives-Adrian, L.,Querol-Audi, J.,Garriga, D.,Pous, J.,Verdaguer, N. (deposition date: 2013-06-05, release date: 2013-11-27, Last modification date: 2018-01-24)
Primary citation
Pickl-Herk, A.,Luque, D.,Vives-Adrian, L.,Querol-Audi, J.,Garriga, D.,Trus, B.L.,Verdaguer, N.,Blaas, D.,Caston, J.R.
Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle.
Proc.Natl.Acad.Sci.USA, 110:20063-20068, 2013
PubMed: 24277846 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1312128110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (6.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.33630.3%1.0%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution