5FX5
Novel inhibitors of human rhinovirus 3C protease
Summary for 5FX5
| Entry DOI | 10.2210/pdb5fx5/pdb |
| Related | 5FX6 |
| Descriptor | RHINOVIRUS 3C PROTEASE, GLYCEROL, TETRAETHYLENE GLYCOL, ... (6 entities in total) |
| Functional Keywords | transferase |
| Biological source | HUMAN RHINOVIRUS 2 (HRV2) |
| Cellular location | Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P04936 |
| Total number of polymer chains | 1 |
| Total formula weight | 21264.09 |
| Authors | Kawatkar, S.,Ek, M.,Hoesch, V.,Gagnon, M.,Nilsson, E.,Lister, T.,Olsson, L.,Patel, J.,Yu, Q. (deposition date: 2016-02-24, release date: 2016-06-22, Last modification date: 2024-01-10) |
| Primary citation | Kawatkar, S.P.,Gagnon, M.,Hoesch, V.,Tiong-Yip, C.,Johnson, K.,Ek, M.,Nilsson, E.,Lister, T.,Olsson, L.,Patel, J.,Yu, Q. Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease. Bioorg.Med.Chem.Lett., 26:3248-, 2016 Cited by PubMed: 27265257DOI: 10.1016/J.BMCL.2016.05.066 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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