2XYA

Non-covalent inhibtors of rhinovirus 3C protease.

Summary for 2XYA

• Entry DOI: 10.2210/pdb2xya/pdb
• Related: 1A3R 1CQQ 1FPN 1V9U 2HRV
• Descriptor: PICORNAIN 3C, 2-PHENYLQUINOLIN-4-OL (3 entities in total)
• Functional Keywords: hydrolase, cysteine protease
• Biological source: HUMAN RHINOVIRUS SP.
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P04936
• Total number of polymer chains: 1
• Total formula weight: 20347.05

Authors

Petersen, J.,Edman, K.,Edfeldt, F.,Johansson, C. (deposition date: 2010-11-16, release date: 2011-04-27, Last modification date: 2024-05-08)

Primary citation

Baxter, A.,Chambers, M.,Edfeldt, F.,Edman, K.,Freeman, A.,Johansson, C.,King, S.,Morley, A.,Petersen, J.,Rawlins, P.,Spadola, L.,Thong, B.,Poel, H.V.,Williams, N.
Non-Covalent Inhibitors of Rhinovirus 3C Protease.
Bioorg.Med.Chem.Lett., 21:777-, 2011

PubMed Abstract: The first known non-covalent inhibitors of rhinovirus 3C protease (3CP) have been identified through fragment based screening and hit identification activities.

PubMed: 21183345
DOI: 10.1016/J.BMCL.2010.11.110

Experimental method

X-RAY DIFFRACTION (2.4 Å)