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PDB: 25 件

6B9X
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Crystal structure of Ragulator
分子名称: Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
著者SU, M.-Y, Hurley, J.H.
登録日2017-10-11
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Mol. Cell, 68, 2017
3MSH
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Crystal structure of Hepatitis B X-Interacting Protein at high resolution
分子名称: GLYCEROL, Hepatitis B virus X-interacting protein, ISOPROPYL ALCOHOL, ...
著者Garcia-Saez, I, Skoufias, D.
登録日2010-04-29
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structural Characterization of HBXIP: The Protein That Interacts with the Anti-Apoptotic Protein Survivin and the Oncogenic Viral Protein HBx.
J.Mol.Biol., 405, 2011
5X6V
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Crystal structure of human heteroheptameric complex
分子名称: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
著者Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M.
登録日2017-02-23
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
5YK5
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structure of the human Lamtor4-Lamtor5 complex
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5
著者Wu, G, Mu, Z.
登録日2017-10-12
公開日2018-12-12
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
Cell Discov, 3, 2017
3MS6
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Crystal structure of Hepatitis B X-Interacting Protein (HBXIP)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Hepatitis B virus X-interacting protein, ...
著者Garcia-Saez, I, Skoufias, D.
登録日2010-04-29
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.085 Å)
主引用文献Structural Characterization of HBXIP: The Protein That Interacts with the Anti-Apoptotic Protein Survivin and the Oncogenic Viral Protein HBx.
J.Mol.Biol., 405, 2011
6EHP
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The crystal structure of the human LAMTOR complex
分子名称: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
著者Scheffzek, K, Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
5X6U
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Crystal structure of human heteropentameric complex
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M.
登録日2017-02-23
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
5Y39
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Crystal structure of Ragulator complex (p18 76-145)
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Zhang, T, Ding, J.
登録日2017-07-28
公開日2017-12-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
5Y38
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Crystal structure of C7orf59-HBXIP complex
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION
著者Zhang, T, Ding, J.
登録日2017-07-28
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Nat Commun, 8, 2017
5VOK
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Crystal structure of the C7orf59-HBXIP dimer
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5
著者Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C.
登録日2017-05-03
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.
Febs Open Bio, 2019
6EHR
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The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Scheffzek, K, Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.898 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
5Y3A
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BU of 5y3a by Molmil
Crystal structure of Ragulator complex (p18 49-161)
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Zhang, T, Ding, J.
登録日2017-07-28
公開日2017-12-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
Nat Commun, 8, 2017
7UX2
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cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Cui, Z, Hurley, J.
登録日2022-05-04
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
5YK3
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human Ragulator complex
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Wu, G, Mu, Z.
登録日2017-10-12
公開日2019-01-23
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
Cell Discov, 3, 2017
6U62
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Raptor-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Rogala, K.B, Sabatini, D.M.
登録日2019-08-29
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structural basis for the docking of mTORC1 on the lysosomal surface.
Science, 366, 2019
6WJ2
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BU of 6wj2 by Molmil
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state
分子名称: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Fromm, S.A, Hurley, J.H.
登録日2020-04-11
公開日2020-09-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
Nat.Struct.Mol.Biol., 27, 2020
7UXH
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cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Cui, Z, Hurley, J.
登録日2022-05-05
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
7UXC
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BU of 7uxc by Molmil
cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Cui, Z, Hurley, J.
登録日2022-05-05
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
6ULG
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BU of 6ulg by Molmil
Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex
分子名称: Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ...
著者Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M.
登録日2019-10-08
公開日2019-11-20
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019
8DHB
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BU of 8dhb by Molmil
Active FLCN GAP complex
分子名称: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ...
著者Jansen, R.M, Hurley, J.H.
登録日2022-06-25
公開日2022-09-28
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
Sci Adv, 8, 2022
6NZD
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Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)
分子名称: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ...
著者Fromm, S.A, Young, L.N, Hurley, J.H.
登録日2019-02-13
公開日2019-11-06
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Science, 366, 2019
7T3B
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GATOR1-RAG-RAGULATOR - GAP Complex
分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
著者Egri, S.B, Shen, K.
登録日2021-12-07
公開日2022-04-06
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
6WJ3
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CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state
分子名称: GUANOSINE-5'-DIPHOSPHATE, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
著者Fromm, S.A, Hurley, J.H.
登録日2020-04-11
公開日2020-09-02
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
Nat.Struct.Mol.Biol., 27, 2020
7T3A
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GATOR1-RAG-RAGULATOR - Inhibitory Complex
分子名称: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
著者Egri, S.B, Shen, K.
登録日2021-12-07
公開日2022-04-06
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3C
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GATOR1-RAG-RAGULATOR - Dual Complex
分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
著者Egri, S.B, Shen, K.
登録日2021-12-07
公開日2022-04-06
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022

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