6TGK
| Domain swapped E6AP C-lobe dimer | 分子名称: | ACETATE ION, CALCIUM ION, Ubiquitin-protein ligase E3A | 著者 | Ries, L.K, Feiler, C, Lowe, L.D, Liess, A.K.L, Lorenz, S. | 登録日 | 2019-11-16 | 公開日 | 2020-02-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP. Protein Sci., 29, 2020
|
|
4JOR
| |
5K4F
| |
6WBJ
| High resolution crystal structure of mRECK(CC4) in fusion with engineered MBP | 分子名称: | GLYCEROL, Maltodextrin-binding protein,Reversion-inducing cysteine-rich protein with Kazal motifs fusion, SULFATE ION, ... | 著者 | Chang, T.H, Hsieh, F.L, Gabelli, S.B, Nathans, J. | 登録日 | 2020-03-26 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Structure of the RECK CC domain, an evolutionary anomaly. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5IC3
| CAL PDZ domain with peptide and inhibitor | 分子名称: | 4-[methyl(nitroso)amino]benzene-1,2-diol, Golgi-associated PDZ and coiled-coil motif-containing protein, HPV18E6 Peptide | 著者 | Zhao, Y, Madden, D.R. | 登録日 | 2016-02-22 | 公開日 | 2017-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | CAL PDZ domain with peptide and inhibitor To Be Published
|
|
8CE0
| N-terminal domain of human apolipoprotein E | 分子名称: | GLYCEROL, Maltodextrin-binding protein,Apolipoprotein E | 著者 | Marek, M, Nemergut, M. | 登録日 | 2023-02-01 | 公開日 | 2023-07-19 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18, 2023
|
|
6ZFG
| 14-3-3 zeta chimera with 18E6 and fusicoccin | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | 著者 | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | 登録日 | 2020-06-17 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
|
|
8OEP
| Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide | 分子名称: | Protein E6, SODIUM ION, Tyrosine-protein phosphatase non-receptor type 3 | 著者 | Genera, M, Colcombet-Cazenave, B, Croitoru, A, Raynal, B, Mechaly, A, Caillet, J, Haouz, A, Wolff, N, Caillet-Saguy, C. | 登録日 | 2023-03-11 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Front Mol Biosci, 10, 2023
|
|
6ZFD
| 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, GLYCEROL | 著者 | Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. | 登録日 | 2020-06-17 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
|
|
8CDY
| N-terminal domain of human apolipoprotein E | 分子名称: | Maltodextrin-binding protein,Apolipoprotein E | 著者 | Marek, M, Nemergut, M. | 登録日 | 2023-02-01 | 公開日 | 2023-07-19 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18, 2023
|
|
6SJV
| Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif | 分子名称: | Maltodextrin-binding protein,Protein E6,Ubiquitin-protein ligase E3A, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Kostmann, C, Mitschler, A, Podjarny, A, Trave, G. | 登録日 | 2019-08-14 | 公開日 | 2019-09-04 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.029 Å) | 主引用文献 | Cellular target recognition by HPV18 and HPV49 oncoproteins To be published
|
|
7CY6
| Crystal Structure of CMD1 in complex with 5mC-DNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(P*(5CM)P*GP*CP*GP*CP*GP*GP*GP*A)-3'), FE (II) ION, ... | 著者 | Li, W, Zhang, T, Sun, M, Ding, J. | 登録日 | 2020-09-03 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
|
|
7CY7
| Crystal Structure of CMD1 in complex with DNA | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(P*CP*GP*CP*GP*CP*GP*GP*GP*A)-3'), FE (II) ION, ... | 著者 | Li, W, Zhang, T, Sun, M, Ding, J. | 登録日 | 2020-09-03 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
|
|
2I04
| X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 | 分子名称: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, SULFATE ION, ... | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | 登録日 | 2006-08-09 | 公開日 | 2007-02-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein. J.Virol., 81, 2007
|
|
7CY5
| Crystal Structure of CMD1 in complex with vitamin C | 分子名称: | ASCORBIC ACID, CITRIC ACID, FE (III) ION, ... | 著者 | Li, W, Zhang, T, Sun, M, Ding, J. | 登録日 | 2020-09-03 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
|
|
4XR8
| Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | 著者 | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | 登録日 | 2015-01-20 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
|
|
7XMN
| Structure of SARS-CoV-2 ORF8 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltodextrin-binding protein, ... | 著者 | Chen, X, Xu, W. | 登録日 | 2022-04-26 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation. Microbiol Spectr, 11, 2023
|
|
2I0L
| X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6. | 分子名称: | Disks large homolog 1, peptide E6 | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | 登録日 | 2006-08-10 | 公開日 | 2007-02-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein. J.Virol., 81, 2007
|
|
7QPB
| Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle | 分子名称: | Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle | 著者 | Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I. | 登録日 | 2022-01-03 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.342 Å) | 主引用文献 | Display Selection of a Hybrid Foldamer-Peptide Macrocycle. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
8JYX
| |
7CY8
| Crystal Structure of CMD1 in complex with 5mC-DNA and vitamin C | 分子名称: | 1,2-ETHANEDIOL, ASCORBIC ACID, DNA (5'-D(P*(5CM)P*GP*CP*GP*CP*GP*GP*GP*A)-3'), ... | 著者 | Li, W, Zhang, T, Sun, M, Ding, J. | 登録日 | 2020-09-03 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
|
|
6WBH
| Crystal structure of mRECK(CC4) in fusion with engineered MBP at medium resolution | 分子名称: | CHLORIDE ION, Maltodextrin-binding protein,Reversion-inducing cysteine-rich protein with Kazal motifs fusion, ZINC ION, ... | 著者 | Chang, T.H, Hsieh, F.L, Gabelli, S.B, Nathans, J. | 登録日 | 2020-03-26 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.455 Å) | 主引用文献 | Structure of the RECK CC domain, an evolutionary anomaly. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
4GIZ
| Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution | 分子名称: | Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein, Protein E6, ... | 著者 | McEwen, A.G, Zanier, K, Charbonnier, S, Poussin, P, Cura, V, Vande Pol, S, Trave, G, Cavarelli, J. | 登録日 | 2012-08-09 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 2013
|
|
8JRN
| Structure of E6AP-E6 complex in Att1 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
|
|
7U0G
| structure of LIN28b nucleosome bound 3 OCT4 | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2022-02-18 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
|
|