6KQD
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![BU of 6kqd by Molmil](/molmil-images/mine/6kqd) | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... | 著者 | Zhang, Y, Li, L, Ebright, R.H. | 登録日 | 2019-08-17 | 公開日 | 2020-03-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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5VO8
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![BU of 5vo8 by Molmil](/molmil-images/mine/5vo8) | X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter | 分子名称: | DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. | 登録日 | 2017-05-02 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5E18
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![BU of 5e18 by Molmil](/molmil-images/mine/5e18) | |
2CW0
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![BU of 2cw0 by Molmil](/molmil-images/mine/2cw0) | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | 分子名称: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | 著者 | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | 登録日 | 2005-06-15 | 公開日 | 2005-09-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
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5X21
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![BU of 5x21 by Molmil](/molmil-images/mine/5x21) | Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) | 分子名称: | (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Zhang, Y, Ebright, R. | 登録日 | 2017-01-29 | 公開日 | 2017-07-05 | 最終更新日 | 2022-10-12 | 実験手法 | X-RAY DIFFRACTION (3.323 Å) | 主引用文献 | Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
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7EH2
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![BU of 7eh2 by Molmil](/molmil-images/mine/7eh2) | |
5X22
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![BU of 5x22 by Molmil](/molmil-images/mine/5x22) | |
4MQ9
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![BU of 4mq9 by Molmil](/molmil-images/mine/4mq9) | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | 分子名称: | (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. | 登録日 | 2013-09-16 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4OIP
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![BU of 4oip by Molmil](/molmil-images/mine/4oip) | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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8HSH
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![BU of 8hsh by Molmil](/molmil-images/mine/8hsh) | Thermus thermophilus RNA polymerase coreenzyme | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-19 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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6LTS
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![BU of 6lts by Molmil](/molmil-images/mine/6lts) | |
6KQN
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![BU of 6kqn by Molmil](/molmil-images/mine/6kqn) | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 6 nt | 分子名称: | DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Zhang, Y, Li, L, Ebright, R.H. | 登録日 | 2019-08-18 | 公開日 | 2020-03-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.489 Å) | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
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4GZY
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![BU of 4gzy by Molmil](/molmil-images/mine/4gzy) | Crystal structures of bacterial RNA Polymerase paused elongation complexes | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Weixlbaumer, A, Leon, K, Landick, R, Darst, S.A. | 登録日 | 2012-09-06 | 公開日 | 2013-02-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.5054 Å) | 主引用文献 | Structural basis of transcriptional pausing in bacteria. Cell(Cambridge,Mass.), 152, 2013
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7MLI
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![BU of 7mli by Molmil](/molmil-images/mine/7mli) | |
7MLB
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![BU of 7mlb by Molmil](/molmil-images/mine/7mlb) | |
3WOD
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![BU of 3wod by Molmil](/molmil-images/mine/3wod) | RNA polymerase-gp39 complex | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. | 登録日 | 2013-12-26 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
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4OIQ
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![BU of 4oiq by Molmil](/molmil-images/mine/4oiq) | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.624 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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7MLJ
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![BU of 7mlj by Molmil](/molmil-images/mine/7mlj) | |
6ASG
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![BU of 6asg by Molmil](/molmil-images/mine/6asg) | Crystal structure of Thermus thermophilus RNA polymerase core enzyme | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | 登録日 | 2017-08-24 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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4G7Z
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![BU of 4g7z by Molmil](/molmil-images/mine/4g7z) | |
8HSR
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![BU of 8hsr by Molmil](/molmil-images/mine/8hsr) | Thermus thermophilus Rho-engaged RNAP elongation complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-20 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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5XJ0
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![BU of 5xj0 by Molmil](/molmil-images/mine/5xj0) | T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. | 登録日 | 2017-04-28 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (4.004 Å) | 主引用文献 | A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
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6M6B
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![BU of 6m6b by Molmil](/molmil-images/mine/6m6b) | Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase and ATP-gamma-S | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Shi, J, Wen, A, Feng, Y. | 登録日 | 2020-03-14 | 公開日 | 2020-10-14 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
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3AOH
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![BU of 3aoh by Molmil](/molmil-images/mine/3aoh) | RNA polymerase-Gfh1 complex (Crystal type 1) | 分子名称: | Anti-cleavage anti-GreA transcription factor Gfh1, DNA (5'-D(*GP*GP*TP*CP*TP*GP*TP*AP*TP*CP*AP*CP*GP*AP*GP*CP*CP*AP*CP*CP*GP*CP*CP*GP*CP*AP*T)-3'), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Tagami, S, Sekine, S, Kumarevel, T, Yamamoto, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2010-09-28 | 公開日 | 2010-12-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein Nature, 468, 2010
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4GZZ
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![BU of 4gzz by Molmil](/molmil-images/mine/4gzz) | Crystal structures of bacterial RNA Polymerase paused elongation complexes | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Weixlbaumer, A, Leon, K, Landick, R, Darst, S.A. | 登録日 | 2012-09-06 | 公開日 | 2013-02-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.2927 Å) | 主引用文献 | Structural basis of transcriptional pausing in bacteria. Cell(Cambridge,Mass.), 152, 2013
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