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PDB: 23 件
3IX3
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LasR-OC12 HSL complex
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein lasR
著者Zou, Y, Nair, S.K.
登録日2009-09-03
公開日2009-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献LasR-OC12 HSL complex
TO BE PUBLISHED
6MWL
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LasR LBD:mBTL complex
分子名称: 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-29
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6D6L
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 14
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-chlorobenzoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-21
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6D6P
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 19
分子名称: N-{[3,5-dibromo-2-(methoxymethoxy)phenyl]methyl}-2-nitrobenzamide, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-21
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6D6O
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 17
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl octanoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-21
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6MWZ
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LasR LBD T75V/Y93F/A127W:BB0126
分子名称: 4-[3-(methylsulfonyl)phenoxy]-N-[(1S,3S,5S)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, ALA-HIS-HIS-HIS-HIS-ALA, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-30
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.657 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6D6B
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 11
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 2-nitrobenzoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-20
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6D6D
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 13
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 2-cyanobenzoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-20
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
2UV0
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Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR
著者Bottomley, M.J, Muraglia, E, Bazzo, R, Carfi, A.
登録日2007-03-08
公開日2007-03-27
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer.
J.Biol.Chem., 282, 2007
3IX4
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BU of 3ix4 by Molmil
LasR-TP1 complex
分子名称: 2,4-dibromo-6-({[(2-nitrophenyl)carbonyl]amino}methyl)phenyl 2-chlorobenzoate, Transcriptional activator protein lasR
著者Zou, Y, Nair, S.K.
登録日2009-09-03
公開日2009-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.
Chem.Biol., 16, 2009
3IX8
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BU of 3ix8 by Molmil
LasR-TP3 complex
分子名称: 2,4-dibromo-6-({[(2-chlorophenyl)carbonyl]amino}methyl)phenyl 2-methylbenzoate, Transcriptional activator protein lasR
著者Zou, Y, Nair, S.K.
登録日2009-09-03
公開日2009-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.
Chem.Biol., 16, 2009
6D6N
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 16
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-methoxybenzoate, PHENYLALANINE, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-21
公開日2018-08-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6D6C
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 12
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 2-methoxybenzoate, HISTIDINE, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-20
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6MVM
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LasR LBD L130F:3OC14HSL complex
分子名称: 3-oxo-N-[(3S)-2-oxooxolan-3-yl]tetradecanamide, Transcriptional regulator LasR
著者Paczkowski, J.E, Bassler, B.L.
登録日2018-10-26
公開日2019-01-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6D6M
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The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 15
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-bromobenzoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-21
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6D6A
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BU of 6d6a by Molmil
The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 10
分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl benzoate, Transcriptional activator protein LasR
著者Dong, S.H, Nair, S.K.
登録日2018-04-20
公開日2018-08-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.
Cell Chem Biol, 25, 2018
6MVN
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LasR LBD L130F:3OC10HSL complex
分子名称: 3-oxo-N-[(3S)-2-oxotetrahydrofuran-3-yl]decanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-26
公開日2019-01-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural determinants driving homoserine lactone ligand selection in thePseudomonas aeruginosaLasR quorum-sensing receptor.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6MWH
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LasR LBD:BB0020 complex
分子名称: 2-(3-bromophenoxy)-N-[(1S,2S,3R,5S)-2-hydroxybicyclo[3.1.0]hexan-3-yl]acetamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-29
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
3JPU
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BU of 3jpu by Molmil
LasR-TP4 complex
分子名称: 4-bromo-2-({[(2-chlorophenyl)carbonyl]amino}methyl)-6-methylphenyl 2,4-dichlorobenzoate, Transcriptional activator protein lasR
著者Zou, Y, Nair, S.K.
登録日2009-09-04
公開日2009-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.
Chem.Biol., 16, 2009
4NG2
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Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein LasR, Uncharacterized protein
著者Fan, H, Wu, D.H, Song, H.
登録日2013-11-01
公開日2013-12-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing
Proc.Natl.Acad.Sci.USA, 110, 2013
6MWW
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LasR LBD:BB0126 complex
分子名称: 4-[3-(methylsulfonyl)phenoxy]-N-[(1R,3R,5R)-2-oxobicyclo[3.1.0]hexan-3-yl]butanamide, Transcriptional regulator LasR
著者Bassler, B.L, Paczkowski, J.E.
登録日2018-10-30
公開日2019-04-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Acs Chem.Biol., 14, 2019
6V7X
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Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, QUORUM SENSING ANTI-ACTIVATOR PROTEIN AQS1, Transcriptional regulator LasR
著者Shah, M, Moraes, T.F, Maxwell, K.L.
登録日2019-12-09
公開日2020-12-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
Mol.Cell, 81, 2021
6V7W
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Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, QUORUM SENSING ANTI-ACTIVATOR PROTEIN AQS1, Transcriptional regulator LasR
著者Shah, M, Moraes, T.F, Maxwell, K.L.
登録日2019-12-09
公開日2020-12-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
Mol.Cell, 81, 2021

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件を2024-07-10に公開中

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