2UV0

Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer

Summary for 2UV0

Entry DOI	10.2210/pdb2uv0/pdb
Descriptor	TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR, N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE (3 entities in total)
Functional Keywords	transcription, acyl-homoserine lactone receptor, quorum sensing, transcription regulation, alpha-beta-alpha sandwich
Biological source	PSEUDOMONAS AERUGINOSA
Total number of polymer chains	4
Total formula weight	79935.42
Authors	Bottomley, M.J.,Muraglia, E.,Bazzo, R.,Carfi, A. (deposition date: 2007-03-08, release date: 2007-03-27, Last modification date: 2019-07-24)
Primary citation	Bottomley, M.J.,Muraglia, E.,Bazzo, R.,Carfi, A. Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer. J.Biol.Chem., 282:13592-, 2007 Cited by PubMed: 17363368 DOI: 10.1074/JBC.M700556200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation