6D6A

The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 10

Summary for 6D6A

• Entry DOI: 10.2210/pdb6d6a/pdb
• Descriptor: Transcriptional activator protein LasR, 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl benzoate (3 entities in total)
• Functional Keywords: luxr receptor, signaling protein-agonist complex, signaling protein/agonist
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 8
• Total formula weight: 156340.98

Authors

Dong, S.H.,Nair, S.K. (deposition date: 2018-04-20, release date: 2018-08-08, Last modification date: 2024-03-13)

• Primary citation: O'Reilly, M.C.,Dong, S.H.,Rossi, F.M.,Karlen, K.M.,Kumar, R.S.,Nair, S.K.,Blackwell, H.E.; Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.; Cell Chem Biol, 25:1128-1139.e3, 2018; PubMed: 30033130; DOI: 10.1016/j.chembiol.2018.06.007

Experimental method

X-RAY DIFFRACTION (1.9 Å)