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PDB: 175 件
4LLD
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BU of 4lld by Molmil
Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A
分子名称: Ig gamma-1 chain C region, Ig lambda-2 chain C region
著者Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S.
登録日2013-07-09
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Nat.Biotechnol., 32, 2014
3TV3
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BU of 3tv3 by Molmil
Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with Man9
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMYLAMINE, GLYCEROL, ...
著者Pejchal, R, Wilson, I.A.
登録日2011-09-19
公開日2011-10-19
最終更新日2021-04-28
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
4LLQ
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Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 2 beta, CRD2b) at 1.42A
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, mutated CH1, mutated light chain Clambda
著者Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S.
登録日2013-07-09
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Nat.Biotechnol., 32, 2014
5HSF
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BU of 5hsf by Molmil
1.52 Angstrom Crystal Structure of Fc fragment of Human IgG1.
分子名称: Ig gamma-1 chain C region, TRIETHYLENE GLYCOL
著者Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Flores, K, Bishop, B, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2016-01-25
公開日2016-02-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献1.52 Angstrom Crystal Structure of Fc fragment of Human IgG1.
To Be Published
6YT7
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BU of 6yt7 by Molmil
GLYCOSYLATED KNOB/DUMMY-HOLE FC FRAGMENT
分子名称: Ig gamma-1 chain C region, Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Kuglstatter, A, Leibrock, L, Benz, J.
登録日2020-04-24
公開日2020-10-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.
Nat Commun, 11, 2020
4NWU
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BU of 4nwu by Molmil
Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1
分子名称: APE1551 Ab Fab heavy chain, APE1551 Ab Fab light chain
著者Verdino, P, Stanfield, R.L, Wilson, I.A.
登録日2013-12-06
公開日2014-10-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.
J.Biol.Chem., 289, 2014
1L6X
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FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C
分子名称: IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN CONSTANT REGION, Minimized B-domain of Protein A Z34C, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Idusogie, E.E, Presta, L.G, Santoro-Gazzano, H, Totpal, K, Wong, P.Y, Ultsch, M, Meng, Y.G, Mullkerrin, M.G.
登録日2002-03-14
公開日2002-04-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.
J.Immunol., 164, 2000
3TWC
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BU of 3twc by Molmil
Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9
分子名称: AMYLAMINE, PGT127 heavy chain, Ig gamma-1 chain C region, ...
著者Pejchal, R, Wilson, I.A.
登録日2011-09-21
公開日2011-10-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
5JIH
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Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
3MCL
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BU of 3mcl by Molmil
Anti-beta-amyloid antibody c706 fab in space group P21
分子名称: C706 MONOCLONAL HEAVY CHAIN, C706 MONOCLONAL LIGHT CHAIN
著者Teplyakov, A, Obmolova, G, Gilliland, G.L.
登録日2010-03-29
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献His-tag binding by antibody C706 mimics Beta-amyloid recognition.
J.Mol.Recognit., 24, 2010
5U66
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BU of 5u66 by Molmil
Modified single helix from the B-domain of protein A bound to IgG1 Fc
分子名称: IgG1 fc derived from CD4-fc fusion, STAPLED PEPTIDE FROM DOMAIN B OF PROTEIN A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Ultsch, M.H, Eigenbrot, C.
登録日2016-12-07
公開日2017-05-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix.
Protein Eng. Des. Sel., 30, 2017
4NWT
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BU of 4nwt by Molmil
Crystal structure of the anti-human NGF Fab APE1531
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, APE1531 Ab Fab heavy chain, ...
著者Verdino, P, Stanfield, R.L, Wilson, I.A.
登録日2013-12-06
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.
J.Biol.Chem., 289, 2014
4LLM
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BU of 4llm by Molmil
Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A
分子名称: Ig gamma-1 chain C region, Ig lambda-2 chain C region
著者Pustilnik, A, Lewis, S.M, Wu, X, Sereno, A, Huang, F, Guntas, G, Leaver-Fay, A, Smith, E.M, Ho, C, Hansen-Estruch, C, Chamberlain, A.K, Truhlar, S.M, Kuhlman, B, Demarest, S.J, Atwell, S.
登録日2013-07-09
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Nat.Biotechnol., 32, 2014
4BSV
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BU of 4bsv by Molmil
Heterodimeric Fc Antibody Azymetric Variant 1
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2, ...
著者Suits, M.D.L, Spreter, T, Cabrera, E.E, Dixit, S.B, Lario, P.I, Poon, D.K.Y, D'Angelo, I.E.P, Boulanger, M.J.
登録日2013-06-11
公開日2013-08-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Improving Biophysical Properties of a Bispecific Antibody Scaffold to Aid Developability: Quality by Molecular Design.
Mabs, 5, 2013
3DJ9
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BU of 3dj9 by Molmil
Crystal Structure of an isolated, unglycosylated antibody CH2 domain
分子名称: Ig gamma-1 chain C region
著者Prabakaran, P, Vu, B.K, Gan, J, Dimitrov, D.S, Ji, X.
登録日2008-06-22
公開日2008-09-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of an isolated unglycosylated antibody C(H)2 domain.
Acta Crystallogr.,Sect.D, 64, 2008
4XMP
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BU of 4xmp by Molmil
Crystal structure of broadly and potently neutralizing antibody VRC08 in complex with HIV-1 clade A strain Q842.d12 gp120
分子名称: (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, ...
著者Zhou, T, Srivatsan, S, Kwong, P.D.
登録日2015-01-15
公開日2015-04-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7831 Å)
主引用文献Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell, 161, 2015
5JII
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BU of 5jii by Molmil
Crystal structure of human IgG1-Fc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ...
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
4W4N
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BU of 4w4n by Molmil
Crystal structure of human Fc at 1.80 A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Caaveiro, J.M.M, Kiyoshi, M, Tsumoto, K.
登録日2014-08-15
公開日2015-04-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for binding of human IgG1 to its high-affinity human receptor Fc gamma RI
Nat Commun, 6, 2015
4W4O
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BU of 4w4o by Molmil
High-resolution crystal structure of Fc bound to its human receptor Fc-gamma-RI
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ...
著者Caaveiro, J.M.M, Kiyoshi, M, Tsumoto, K.
登録日2014-08-15
公開日2015-04-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for binding of human IgG1 to its high-affinity human receptor Fc gamma RI
Nat Commun, 6, 2015
5HYF
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BU of 5hyf by Molmil
Glycosylated Knob-Knob Fc fragment (P6122)
分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Kuglstatter, A, Stihle, M, Benz, J.
登録日2016-02-01
公開日2017-02-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.
Protein Eng. Des. Sel., 30, 2017
1N7M
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BU of 1n7m by Molmil
Germline 7G12 with N-methylmesoporphyrin
分子名称: Germline Metal Chelatase Catalytic Antibody, chain H, chain L, ...
著者Yin, J, Andryski, S.E, Beuscher IV, A.E, Stevens, R.C, Schultz, P.G.
登録日2002-11-15
公開日2003-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
5JIK
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BU of 5jik by Molmil
Crystal structure of HER2 binding IgG1-Fc (Fcab H10-03-6)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
1AQK
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THREE-DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID
分子名称: FAB B7-15A2
著者Faber, C, Fan, Z, Edmundson, A.B.
登録日1997-07-30
公開日1998-02-04
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Three-dimensional structure of a human Fab with high affinity for tetanus toxoid.
Immunotechnology, 3, 1998
4O4Y
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BU of 4o4y by Molmil
Crystal structure of the anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide
分子名称: 2095-2 heavy chain, 2095-2 light chain, GLYCEROL, ...
著者Malia, T.J, Teplyakov, A, Luo, J, Gilliland, G.L.
登録日2013-12-19
公開日2014-03-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.
Proteins, 82, 2014
5GSQ
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Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, C.-L, Hsu, J.-C, Lin, C.-W, Wu, C.-Y, Wong, C.-H, Ma, C.
登録日2016-08-17
公開日2017-06-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity
ACS Chem. Biol., 12, 2017

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