5GSQ
Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity
Summary for 5GSQ
Entry DOI | 10.2210/pdb5gsq/pdb |
Descriptor | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | antibody fc, homogeneous n-glycan, enhanced adcc, di-sialylation, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 106418.35 |
Authors | Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wu, C.-Y.,Wong, C.-H.,Ma, C. (deposition date: 2016-08-17, release date: 2017-06-28, Last modification date: 2023-11-08) |
Primary citation | Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wang, C.-H.,Tsai, M.-H.,Wu, C.-Y.,Wong, C.-H.,Ma, C. Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity ACS Chem. Biol., 12:1335-1345, 2017 Cited by PubMed: 28318221DOI: 10.1021/acschembio.7b00140 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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