3TWC

Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9

Summary for 3TWC

• Entry DOI: 10.2210/pdb3twc/pdb
• Related: 3TV3 3TYG
• Descriptor: PGT127 light chain, Ig lambda-2 chain C regions, PGT127 heavy chain, Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, ... (5 entities in total)
• Functional Keywords: fab, hiv-1 neutralizing antibody, gp120, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 49452.81

Authors

Pejchal, R.,Wilson, I.A. (deposition date: 2011-09-21, release date: 2011-10-19, Last modification date: 2023-09-13)

• Primary citation: Pejchal, R.,Doores, K.J.,Walker, L.M.,Khayat, R.,Huang, P.S.,Wang, S.K.,Stanfield, R.L.,Julien, J.P.,Ramos, A.,Crispin, M.,Depetris, R.,Katpally, U.,Marozsan, A.,Cupo, A.,Maloveste, S.,Liu, Y.,McBride, R.,Ito, Y.,Sanders, R.W.,Ogohara, C.,Paulson, J.C.,Feizi, T.,Scanlan, C.N.,Wong, C.H.,Moore, J.P.,Olson, W.C.,Ward, A.B.,Poignard, P.,Schief, W.R.,Burton, D.R.,Wilson, I.A.; A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.; Science, 334:1097-1103, 2011; PubMed: 21998254; DOI: 10.1126/science.1213256

Experimental method

X-RAY DIFFRACTION (1.65 Å)