5HYF

Glycosylated Knob-Knob Fc fragment (P6122)

Summary for 5HYF

Entry DOI	10.2210/pdb5hyf/pdb
Related	5HY9 5HYE
Descriptor	Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	bispecific antibody fc engineering knob-into-hole, immune system
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P01857
Total number of polymer chains	1
Total formula weight	27307.62
Authors	Kuglstatter, A.,Stihle, M.,Benz, J. (deposition date: 2016-02-01, release date: 2017-02-01, Last modification date: 2024-01-10)
Primary citation	Kuglstatter, A.,Stihle, M.,Neumann, C.,Muller, C.,Schaefer, W.,Klein, C.,Benz, J. Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products. Protein Eng. Des. Sel., 30:649-656, 2017 Cited by PubMed: 28985438 DOI: 10.1093/protein/gzx041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation