4H1D
| Cocrystal structure of GlpG and DFP | Descriptor: | DIISOPROPYL PHOSPHONATE, Rhomboid protease GlpG | Authors: | Xue, Y, Ha, Y. | Deposit date: | 2012-09-10 | Release date: | 2013-05-01 | Last modified: | 2013-06-26 | Method: | X-RAY DIFFRACTION (2.8975 Å) | Cite: | Large lateral movement of transmembrane helix s5 is not required for substrate access to the active site of rhomboid intramembrane protease. J.Biol.Chem., 288, 2013
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3ODJ
| Crystal structure of H. influenzae rhomboid GlpG with disordered loop 4, helix 5 and loop 5 | Descriptor: | Rhomboid protease glpG | Authors: | Brooks, C.L, Lazareno-Saez, C, Lamoureux, J.S, Mak, M.W, Lemieux, M.J. | Deposit date: | 2010-08-11 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Insights into Substrate Gating in H. influenzae Rhomboid. J.Mol.Biol., 407, 2011
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8AB5
| Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] | Descriptor: | Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl], Rhomboid protease GlpG | Authors: | Skerlova, J, Polovinkin, V, Bach, K, Borshchevskiy, V, Strisovsky, K. | Deposit date: | 2022-07-04 | Release date: | 2023-10-25 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency. Eur.J.Med.Chem., 275, 2024
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2IC8
| Crystal structure of GlpG | Descriptor: | Protein glpG, nonyl beta-D-glucopyranoside | Authors: | Ha, Y. | Deposit date: | 2006-09-12 | Release date: | 2006-10-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
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2IRV
| Crystal structure of GlpG, a rhomboid intramembrane serine protease | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Bibi, E, Fass, D, Ben-Shem, A. | Deposit date: | 2006-10-16 | Release date: | 2006-10-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc.Natl.Acad.Sci.Usa, 104, 2007
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6XRP
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6XRO
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4NJN
| Crystal Structure of E.coli GlpG at pH 4.5 | Descriptor: | Rhomboid protease GlpG | Authors: | Dickey, S.W, Baker, R.P, Cho, S, Urban, S. | Deposit date: | 2013-11-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
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3B45
| Crystal structure of GlpG at 1.9A resolution | Descriptor: | glpG, nonyl beta-D-glucopyranoside | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | Deposit date: | 2007-10-23 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
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4NJP
| Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity | Descriptor: | Rhomboid protease GlpG | Authors: | Dickey, S.W, Baker, R.P, Cho, S, Urban, S. | Deposit date: | 2013-11-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013
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6VJ8
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3UBB
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6VJ9
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3TXT
| Crystal structure of GlpG in complex with inhibitor DFP | Descriptor: | DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG | Authors: | Xue, Y, Ha, Y. | Deposit date: | 2011-09-23 | Release date: | 2011-12-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor To be Published
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3B44
| Crystal structure of GlpG W136A mutant | Descriptor: | glpG, nonyl beta-D-glucopyranoside | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | Deposit date: | 2007-10-23 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
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2NRF
| Crystal Structure of GlpG, a Rhomboid family intramembrane protease | Descriptor: | Protein GlpG | Authors: | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | Deposit date: | 2006-11-02 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
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2O7L
| The open-cap conformation of GlpG | Descriptor: | Protein glpG, nonyl beta-D-glucopyranoside | Authors: | Ha, Y. | Deposit date: | 2006-12-11 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Open-cap conformation of intramembrane protease GlpG. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2NR9
| Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae | Descriptor: | (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, Protein glpG homolog | Authors: | Lemieux, M.J, Fischer, S.J, Cherney, M.M, Bateman, K.S, James, M.N.G. | Deposit date: | 2006-11-01 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc.Natl.Acad.Sci.USA, 104, 2007
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5MT7
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2XOW
| Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor | Descriptor: | 5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC ACID, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside | Authors: | Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. | Deposit date: | 2010-08-24 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The Structural Basis for Catalysis and Substrate Specificity of a Rhomboid Protease Embo J., 29, 2010
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5MT6
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5MT8
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5MTF
| A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases | Descriptor: | CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... | Authors: | Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. | Deposit date: | 2017-01-09 | Release date: | 2017-11-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
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2XTU
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2XTV
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