PDB: 615 resultsInfo pagesStatus searchChemie searchBIRD

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3UBW	Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen Descriptor: (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ... Authors: Molzan, M, Weyand, M, Rose, R, Ottmann, C. Deposit date: 2011-10-25 Release date: 2012-01-25 Last modified: 2012-02-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 Descriptor: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... Authors: Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2013-12-18 Release date: 2014-04-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
6KZH	14-3-3 protein in Complex with CIC S173 phosphorylated peptide Descriptor: 14-3-3 protein theta, CIC pS173 peptide Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.645 Å) Cite: 14-3-3 protein in Complex with CIC S173 phosphorylated peptide To Be Published
8HEW	Potato 14-3-3 St14f Descriptor: 14-3-3 protein, StFDL1 peptide Authors: Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. Deposit date: 2022-11-08 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J., 112, 2022
4QLI	A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2014-06-12 Release date: 2015-06-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation To be Published
5ULO	Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, L-PROLINAMIDE, ... Authors: DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC) Deposit date: 2017-01-25 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide to be published
3UX0	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer Fusicoccin H Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(hydroxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-gulopyranoside, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Thiel, P, Bartel, M, Anders, C, Higuchi, Y, Schumacher, B, Kato, N, Ottmann, C. Deposit date: 2011-12-03 Release date: 2013-01-02 Last modified: 2013-05-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
3UZD	Crystal structure of 14-3-3 GAMMA Descriptor: 14-3-3 protein gamma, Histone deacetylase 4, MAGNESIUM ION, ... Authors: Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2011-12-07 Release date: 2012-03-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
4FR3	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... Authors: Ottmann, C, Anders, C, Schumacher, B. Deposit date: 2012-06-26 Release date: 2013-05-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
8EQ8	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130 Descriptor: 14-3-3 protein beta/alpha Authors: Zhu, P, Cooley, R.B. Deposit date: 2022-10-07 Release date: 2023-01-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8EQH	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 Descriptor: 14-3-3 protein beta/alpha Authors: Zhu, P, Cooley, R.B. Deposit date: 2022-10-07 Release date: 2023-01-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase Authors: Ottmann, C, Molzan, M. Deposit date: 2012-06-11 Release date: 2012-09-05 Last modified: 2013-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
7V9B	Crystal Structure of 14-3-3 epsilon with FOXO3a peptide Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN, ... Authors: Mathivanan, S, Kamariah, N. Deposit date: 2021-08-24 Release date: 2022-08-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of a 14-3-3 epsilon :FOXO3a pS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins. Acs Omega, 7, 2022
2V7D	14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide Descriptor: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT Authors: Takala, H, Ylanne, J. Deposit date: 2007-07-30 Release date: 2008-06-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood, 112, 2008
1YWT	Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) Authors: Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. Deposit date: 2005-02-18 Release date: 2005-03-01 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
1YZ5	The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution Descriptor: 14-3-3 protein sigma Authors: Benzinger, A, Popowicz, G.M, Holak, T.A, Hermeking, H. Deposit date: 2005-02-28 Release date: 2005-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res., 15, 2005
2WH0	Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon Descriptor: 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ... Authors: Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q. Deposit date: 2009-04-28 Release date: 2009-08-18 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon. Embo Rep., 10, 2009
7XBQ	Crystal structure of potato 14-3-3 protein St14f Descriptor: Putative 14-3-3 protein Authors: Harada, K, Kojima, C, Yamashita, E, Nakagawa, A. Deposit date: 2022-03-21 Release date: 2022-07-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structure of potato 14-3-3 protein St14f revealed the importance of helix I in StFDL1 recognition. Sci Rep, 12, 2022
6ZCJ	14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 Authors: Soini, L, Leysen, S, Davis, J, Ottmann, C. Deposit date: 2020-06-11 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
3E6Y	Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2008-08-17 Release date: 2009-03-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
3EFZ	Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein Authors: Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) Deposit date: 2008-09-10 Release date: 2008-09-23 Last modified: 2012-02-22 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus Descriptor: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL Authors: Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. Deposit date: 2020-06-17 Release date: 2021-02-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6ZFG	14-3-3 zeta chimera with 18E6 and fusicoccin Descriptor: 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL Authors: Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. Deposit date: 2020-06-17 Release date: 2021-02-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6KZG	14-3-3 protein in Complex with CIC S301 phosphorylated peptide Descriptor: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: 14-3-3 protein in Complex with CIC S301 phosphorylated peptide To Be Published

 

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