4NM2
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![BU of 4nm2 by Molmil](/molmil-images/mine/4nm2) | Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-G at N-1 position and G-C at N position | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*GP*(BGM)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. | Deposit date: | 2013-11-14 | Release date: | 2014-01-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.524 Å) | Cite: | Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
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4EJM
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4NFM
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![BU of 4nfm by Molmil](/molmil-images/mine/4nfm) | Human tau tubulin kinase 1 (TTBK1) | Descriptor: | GLYCEROL, Tau-tubulin kinase 1 | Authors: | Sheriff, S. | Deposit date: | 2013-10-31 | Release date: | 2014-02-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta Crystallogr F Struct Biol Commun, 70, 2014
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4NHG
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![BU of 4nhg by Molmil](/molmil-images/mine/4nhg) | Crystal Structure of 2G12 IgG Dimer | Descriptor: | 2G12 IgG dimer heavy chain, 2G12 IgG dimer light chain, Hepatitis B virus receptor binding protein | Authors: | Wu, Y, West Jr, A.P, Kim, H.J, Thornton, M.E, Ward, A.B, Bjorkman, P.J. | Deposit date: | 2013-11-05 | Release date: | 2014-02-26 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (8.001 Å) | Cite: | Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12. Cell Rep, 5, 2013
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4NJM
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4NLK
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![BU of 4nlk by Molmil](/molmil-images/mine/4nlk) | Structure of human DNA polymerase beta complexed with 8BrG in the template base-paired with incoming non-hydrolyzable CTP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ... | Authors: | Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. | Deposit date: | 2013-11-14 | Release date: | 2014-01-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
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4NQZ
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4NE7
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![BU of 4ne7 by Molmil](/molmil-images/mine/4ne7) | Crystal Structure of engineered Kumamolisin-As from Alicyclobacillus sendaiensis, Northeast Structural Genomics Consortium (NESG) Target OR367 | Descriptor: | Kumamolisin-As, ZINC ION | Authors: | Guan, R, Pultz, I.S, Siegel, J.B, Seetharaman, J, Kornhaber, G, Maglaqui, M, Mao, L, Xiao, R, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-10-28 | Release date: | 2013-11-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.497 Å) | Cite: | Northeast Structural Genomics Consortium Target OR367 To be Published
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4NQY
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![BU of 4nqy by Molmil](/molmil-images/mine/4nqy) | The reduced form of MJ0499 | Descriptor: | Isopropylmalate/citramalate isomerase large subunit, ZINC ION | Authors: | Hwang, K.Y, Lee, E.H, Lee, K. | Deposit date: | 2013-11-26 | Release date: | 2014-05-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii Acta Crystallogr.,Sect.D, 70, 2014
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4NU0
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![BU of 4nu0 by Molmil](/molmil-images/mine/4nu0) | Crystal structure of Adenylate kinase from Streptococcus pneumoniae with Ap5A | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION | Authors: | Thach, T.T, Luong, T.T, Lee, S.H, Rhee, D.K. | Deposit date: | 2013-12-03 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.485 Å) | Cite: | Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity FEBS Open Bio, 4, 2014
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4NUR
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![BU of 4nur by Molmil](/molmil-images/mine/4nur) | Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9 | Descriptor: | MAGNESIUM ION, PSdsA, ZINC ION | Authors: | Sun, L.F, Su, Y.T, Zhao, Y.H, Cai, Z.X, Wu, Y. | Deposit date: | 2013-12-04 | Release date: | 2014-12-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.761 Å) | Cite: | Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9 To be Published
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4NWK
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![BU of 4nwk by Molmil](/molmil-images/mine/4nwk) | Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide | Descriptor: | GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ... | Authors: | Muckelbauer, J.K, Klei, H.E. | Deposit date: | 2013-12-06 | Release date: | 2014-03-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
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4NE6
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![BU of 4ne6 by Molmil](/molmil-images/mine/4ne6) | Human MHF1-MHF2 complex | Descriptor: | Centromere protein S, Centromere protein X | Authors: | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | Deposit date: | 2013-10-28 | Release date: | 2013-12-25 | Last modified: | 2014-02-12 | Method: | X-RAY DIFFRACTION (2.1001 Å) | Cite: | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
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4NG9
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4KSA
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![BU of 4ksa by Molmil](/molmil-images/mine/4ksa) | Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127 | Descriptor: | MAGNESIUM ION, Malonyl-CoA decarboxylase | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Sahdev, S, Xiao, R, Patel, D.J, Ciccosanti, C, Wang, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-05-17 | Release date: | 2013-06-19 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure, 21, 2013
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4K88
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![BU of 4k88 by Molmil](/molmil-images/mine/4k88) | Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Proline--tRNA ligase, ZINC ION | Authors: | Hwang, K.Y, Son, J.H, Lee, E.H. | Deposit date: | 2013-04-18 | Release date: | 2013-10-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.619 Å) | Cite: | Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69, 2013
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4EDM
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![BU of 4edm by Molmil](/molmil-images/mine/4edm) | Crystal structure of beta-parvin CH2 domain | Descriptor: | 1,2-ETHANEDIOL, Beta-parvin | Authors: | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | Deposit date: | 2012-03-27 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. J.Biol.Chem., 287, 2012
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4KNV
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![BU of 4knv by Molmil](/molmil-images/mine/4knv) | The crystal structure of APO HUMAN HDHD4 FROM SE-MAD | Descriptor: | MAGNESIUM ION, N-acylneuraminate-9-phosphatase, PHOSPHATE ION | Authors: | Klei, H.E. | Deposit date: | 2013-05-10 | Release date: | 2013-06-26 | Last modified: | 2013-07-10 | Method: | X-RAY DIFFRACTION (1.993 Å) | Cite: | Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex. Bioorg.Med.Chem.Lett., 23, 2013
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4KHB
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![BU of 4khb by Molmil](/molmil-images/mine/4khb) | Structure of the Spt16D Pob3N heterodimer | Descriptor: | SULFATE ION, Uncharacterized protein POB3N, Uncharacterized protein SPT16D | Authors: | Stuwe, T, Zhang, E, Ladurner, A.G. | Deposit date: | 2013-04-30 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature, 499, 2013
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4KP1
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![BU of 4kp1 by Molmil](/molmil-images/mine/4kp1) | Crystal structure of IPM isomerase large subunit from methanococcus jannaschii (MJ0499) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,4-dimethylpentane-2,4-diol, Isopropylmalate/citramalate isomerase large subunit, ... | Authors: | Hwang, K.Y, Lee, E.H. | Deposit date: | 2013-05-13 | Release date: | 2014-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii Acta Crystallogr.,Sect.D, 70, 2014
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4ETK
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![BU of 4etk by Molmil](/molmil-images/mine/4etk) | Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186 | Descriptor: | De novo designed serine hydrolase, SODIUM ION | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-24 | Release date: | 2012-06-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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4EUH
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![BU of 4euh by Molmil](/molmil-images/mine/4euh) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase apo form | Descriptor: | Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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4EXO
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![BU of 4exo by Molmil](/molmil-images/mine/4exo) | Revised, rerefined crystal structure of PDB entry 2QHK, methyl accepting chemotaxis protein | Descriptor: | Methyl-accepting chemotaxis protein, PYRUVIC ACID | Authors: | Sweeney, E.G, Henderson, J.N, Goers, J, Wreden, C, Hicks, K.G, Foster, J.K, Parthasarathy, R, Remington, S.J, Guillemin, K. | Deposit date: | 2012-04-30 | Release date: | 2012-05-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Proposed Mechanism for the pH-Sensing Helicobacter pylori Chemoreceptor TlpB. Structure, 20, 2012
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4NJO
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4NLD
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![BU of 4nld by Molmil](/molmil-images/mine/4nld) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide | Descriptor: | (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ... | Authors: | Sheriff, S. | Deposit date: | 2013-11-14 | Release date: | 2014-03-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase. J.Med.Chem., 57, 2014
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