PDB: 47065 resultsInfo pagesStatus searchChemie searchBIRD

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6DHW	Crystal structure of primase iron-sulfur domain (266-457) Descriptor: DNA primase large subunit, IRON/SULFUR CLUSTER, SULFATE ION Authors: Holt, M.E, Salay, L.E, Chazin, W.J. Deposit date: 2018-05-21 Release date: 2018-12-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.013 Å) Cite: Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs. PLoS ONE, 13, 2018
7P5T	Structure of CYP142 from Mycobacterium tuberculosis in complex with inhibitor MEK216 Descriptor: BROMIDE ION, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Snee, M, Kavanagh, M, Tunnicliffe, R, McLean, K, Levy, C, Munro, A. Deposit date: 2021-07-14 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure of CYP142 from Mycobacterium tuberculosis in complex with inhibitor MEK216 To Be Published
7PA0	NaK C-DI F92A mutant with Rb+ and K+ Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... Authors: Minniberger, S, Plested, A.J.R. Deposit date: 2021-07-28 Release date: 2022-08-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
6DAZ	X-ray crystal structure of VioC bound to Fe(II), 3S-hydroxy-L-homoarginine, and succinate Descriptor: (3S)-N~6~-carbamimidoyl-3-hydroxy-L-lysine, Alpha-ketoglutarate-dependent L-arginine hydroxylase, FE (II) ION, ... Authors: Dunham, N.P, Mitchell, A.J, Boal, A.K. Deposit date: 2018-05-02 Release date: 2018-05-16 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance. J. Am. Chem. Soc., 140, 2018
6DON	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 100 mM K+ for 120 s at 21 C (dataset 1) Descriptor: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.422 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7PA7	BK polyomavirus VP1 in complex with scFv 29B1 Descriptor: Major capsid protein VP1, scFv 29B1 antibody heavy chain Authors: Harprecht, C, Stroeh, L.J, Freytag, J, Stehle, T. Deposit date: 2021-07-29 Release date: 2023-02-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural characterization of human neutralizing antibodies against JC and BK polyomavirus To Be Published
7Z4E	SpCas9 bound to 8-nucleotide complementary DNA substrate Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ... Authors: Pacesa, M, Jinek, M. Deposit date: 2022-03-03 Release date: 2022-08-31 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
7PEL	CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma Descriptor: DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... Authors: Barski, M, Pye, V.E, Nans, A, Cherepanov, P, Maertens, G.N. Deposit date: 2021-08-10 Release date: 2021-08-25 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.34 Å) Cite: Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma. Nat Commun, 11, 2020
7ZB2	apo macrocyclase OphP Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Song, H, Naismith, J.H. Deposit date: 2022-03-23 Release date: 2022-07-06 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides Biorxiv, 2022
7Z4C	SpCas9 bound to 6 nucleotide complementary DNA substrate Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ... Authors: Pacesa, M, Jinek, M. Deposit date: 2022-03-03 Release date: 2022-08-31 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.87 Å) Cite: R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
7Z4G	SpCas9 bound to 12-nucleotide complementary DNA substrate Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ... Authors: Pacesa, M, Jinek, M. Deposit date: 2022-03-03 Release date: 2022-08-31 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
7PJF	Inhibiting parasite proliferation using a rationally designed anti-tubulin agent Descriptor: Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. Deposit date: 2021-08-24 Release date: 2021-09-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.862 Å) Cite: Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
7Z4K	SpCas9 bound to 10-nucleotide complementary DNA substrate Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ... Authors: Pacesa, M, Jinek, M. Deposit date: 2022-03-04 Release date: 2022-08-31 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: R-loop formation and conformational activation mechanisms of Cas9. Nature, 609, 2022
6DOK	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 25 mM K+ for 120 s at 21 C (dataset 1) Descriptor: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), 5'-R(P*CP*G)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DOY	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM Li+ for 120 s at 21 C Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7PKO	CryoEM structure of Rotavirus NSP2 Descriptor: Non-structural protein 2 Authors: Bravo, J.P.K, Borodavka, A. Deposit date: 2021-08-26 Release date: 2021-09-29 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proc.Natl.Acad.Sci.USA, 118, 2021
6DPC	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 12 mM Mn2+ and 200 mM K+ for 40 s at 21 C Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... Authors: Samara, N.L, Yang, W. Deposit date: 2018-06-09 Release date: 2018-08-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DQ6	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N44 i.e. 3-((2-(pyridin-2-yl)-6-(4-(vinylsulfonyl)-1,4-diazepan-1-yl)pyrimidin-4-yl)amino)propanoic acid Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Linked KDM5A Jmj Domain, ... Authors: Horton, J.R, Cheng, X. Deposit date: 2018-06-10 Release date: 2018-11-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.587 Å) Cite: Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J. Med. Chem., 61, 2018
7PKP	NSP2 RNP complex Descriptor: Non-structural protein 2 Authors: Bravo, J.P.K, Borodavka, A. Deposit date: 2021-08-26 Release date: 2021-09-29 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proc.Natl.Acad.Sci.USA, 118, 2021
6DQF	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N68 i.e. 2-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)thieno[3,2-b]pyridine-7-carboxylic acid Descriptor: 2-{1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-yl}thieno[3,2-b]pyridine-7-carboxylic acid, Linked KDM5A Jmj Domain, MANGANESE (II) ION Authors: Horton, J.R, Cheng, X. Deposit date: 2018-06-10 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.688 Å) Cite: To be determined To Be Published
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form Descriptor: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... Authors: Scaletti, E.R, Strater, N. Deposit date: 2021-08-04 Release date: 2021-10-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6DFV	Mouse diabetogenic TCR 8F10 Descriptor: 1,2-ETHANEDIOL, TCR alpha chain, TCR beta chain Authors: Wang, Y, Dai, S. Deposit date: 2018-05-15 Release date: 2019-04-17 Method: X-RAY DIFFRACTION (1.71 Å) Cite: How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol, 4, 2019
7PCP	Crystal structure of CD73 in complex with 5-iodouracil in the open form Descriptor: 5'-nucleotidase, 5-IODOURACIL, CALCIUM ION, ... Authors: Scaletti, E.R, Strater, N. Deposit date: 2021-08-03 Release date: 2021-10-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.377 Å) Cite: Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6DRV	Beta-galactosidase Descriptor: Beta-galactosidase Authors: Cianfrocco, M.A, Lahiri, I, DiMaio, F, Leschziner, A.E. Deposit date: 2018-06-13 Release date: 2018-07-11 Last modified: 2020-01-08 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. J. Struct. Biol., 203, 2018
7PER	Model of the inner ring of the human nuclear pore complex Descriptor: Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ... Authors: Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U. Deposit date: 2021-08-11 Release date: 2021-10-20 Last modified: 2021-11-24 Method: ELECTRON MICROSCOPY (35 Å) Cite: The cellular environment shapes the nuclear pore complex architecture. Nature, 598, 2021

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