1Y77
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![BU of 1y77 by Molmil](/molmil-images/mine/1y77) | Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP | Descriptor: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*T*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*G)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | Deposit date: | 2004-12-08 | Release date: | 2005-01-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS Mol.Cell, 16, 2004
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1Y1W
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![BU of 1y1w by Molmil](/molmil-images/mine/1y1w) | Complete RNA Polymerase II elongation complex | Descriptor: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*AP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | Authors: | Cramer, P, Kettenberger, H, Armache, K.-J. | Deposit date: | 2004-11-19 | Release date: | 2005-01-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS Mol.Cell, 16, 2004
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1Y1V
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![BU of 1y1v by Molmil](/molmil-images/mine/1y1v) | Refined RNA Polymerase II-TFIIS complex | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | Deposit date: | 2004-11-19 | Release date: | 2004-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol.Cell, 16, 2004
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2A1A
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![BU of 2a1a by Molmil](/molmil-images/mine/2a1a) | PKR kinase domain-eIF2alpha Complex | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | Deposit date: | 2005-06-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
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4QIW
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![BU of 4qiw by Molmil](/molmil-images/mine/4qiw) | |
7ZSB
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![BU of 7zsb by Molmil](/molmil-images/mine/7zsb) | |
7ZSA
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![BU of 7zsa by Molmil](/molmil-images/mine/7zsa) | |
7ZS9
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![BU of 7zs9 by Molmil](/molmil-images/mine/7zs9) | |
8A3L
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![BU of 8a3l by Molmil](/molmil-images/mine/8a3l) | Structural insights into the binding of bS1 to the ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | Authors: | D'Urso, G, Chat, S, Gillet, R, Giudice, E. | Deposit date: | 2022-06-08 | Release date: | 2023-05-10 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Structural insights into the binding of bS1 to the ribosome. Nucleic Acids Res., 51, 2023
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8A40
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![BU of 8a40 by Molmil](/molmil-images/mine/8a40) | Structure of mammalian Pol II-TFIIS elongation complex | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | Deposit date: | 2022-06-09 | Release date: | 2023-08-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol.Cell, 82, 2022
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8B3F
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![BU of 8b3f by Molmil](/molmil-images/mine/8b3f) | Pol II-CSB-CSA-DDB1-ELOF1 | Descriptor: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pol II-CSB-CSA-DDB1-ELOF1 structure. To Be Published
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8B3D
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![BU of 8b3d by Molmil](/molmil-images/mine/8b3d) | Structure of the Pol II-TCR-ELOF1 complex. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA damage-binding protein 1, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure of the Pol II-TCR-ELOF1 complex. To Be Published
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2B63
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![BU of 2b63 by Molmil](/molmil-images/mine/2b63) | Complete RNA Polymerase II-RNA inhibitor complex | Descriptor: | 31-MER, DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, ... | Authors: | Kettenberger, H, Eisenfuehr, A, Brueckner, F, Theis, M, Famulok, M, Cramer, P. | Deposit date: | 2005-09-30 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs Nat.Struct.Mol.Biol., 13, 2006
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8BVW
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![BU of 8bvw by Molmil](/molmil-images/mine/8bvw) | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | Deposit date: | 2022-12-20 | Release date: | 2023-05-03 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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2B8K
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![BU of 2b8k by Molmil](/molmil-images/mine/2b8k) | 12-subunit RNA Polymerase II | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | Authors: | Meyer, P.A, Ye, P, Zhang, M, Suh, M.H, Fu, J. | Deposit date: | 2005-10-07 | Release date: | 2006-06-20 | Last modified: | 2012-06-13 | Method: | X-RAY DIFFRACTION (4.15 Å) | Cite: | Phasing RNA Polymerase II Using Intrinsically Bound Zn Atoms: An Updated Structural Model. Structure, 14, 2006
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2AHO
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![BU of 2aho by Molmil](/molmil-images/mine/2aho) | Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus solfataricus complexed with GDPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Translation initiation factor 2 alpha subunit, ... | Authors: | Yatime, L, Mechulam, Y, Blanquet, S, Schmitt, E. | Deposit date: | 2005-07-28 | Release date: | 2006-01-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Switch of the gamma Subunit in an Archaeal aIF2alphagamma Heterodimer Structure, 14, 2006
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6QG1
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![BU of 6qg1 by Molmil](/molmil-images/mine/6qg1) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 2) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6QDV
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![BU of 6qdv by Molmil](/molmil-images/mine/6qdv) | Human post-catalytic P complex spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. | Deposit date: | 2019-01-03 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science, 363, 2019
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6QG2
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![BU of 6qg2 by Molmil](/molmil-images/mine/6qg2) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model A) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6QG6
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![BU of 6qg6 by Molmil](/molmil-images/mine/6qg6) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model D) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.65 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6QG0
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![BU of 6qg0 by Molmil](/molmil-images/mine/6qg0) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 1) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6O9L
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![BU of 6o9l by Molmil](/molmil-images/mine/6o9l) | Human holo-PIC in the closed state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | Deposit date: | 2019-03-14 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
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6QG3
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![BU of 6qg3 by Molmil](/molmil-images/mine/6qg3) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model B) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6QG5
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![BU of 6qg5 by Molmil](/molmil-images/mine/6qg5) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model C) | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (10.1 Å) | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6O9Z
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![BU of 6o9z by Molmil](/molmil-images/mine/6o9z) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Nguyen, H.C, Kenner, L.R, Frost, A.S. | Deposit date: | 2019-03-15 | Release date: | 2019-05-15 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science, 364, 2019
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