6S7F
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2BCD
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![BU of 2bcd by Molmil](/molmil-images/mine/2bcd) | X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound | Descriptor: | BETA-MERCAPTOETHANOL, MANGANESE (II) ION, MOTUPORIN, ... | Authors: | Maynes, J.T, Luu, H.A, Cherney, M.M, Andersen, R.J, Williams, D, Holmes, C.F, James, M.N. | Deposit date: | 2005-10-19 | Release date: | 2006-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins. J.Mol.Biol., 356, 2006
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5F3W
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![BU of 5f3w by Molmil](/molmil-images/mine/5f3w) | Structure of the ATPrS-Mre11/Rad50-DNA complex | Descriptor: | 27-MER DNA, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA double-strand break repair protein Mre11, ... | Authors: | Liu, Y. | Deposit date: | 2015-12-03 | Release date: | 2016-03-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex Embo J., 35, 2016
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5FC5
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![BU of 5fc5 by Molmil](/molmil-images/mine/5fc5) | Murine SMPDL3A in complex with phosphocholine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | Authors: | Gorelik, A, Illes, K, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-14 | Release date: | 2016-01-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.678 Å) | Cite: | Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J.Biol.Chem., 291, 2016
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1HO5
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1HPU
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![BU of 1hpu by Molmil](/molmil-images/mine/1hpu) | 5'-NUCLEOTIDASE (CLOSED FORM), COMPLEX WITH AMPCP | Descriptor: | 5'-NUCLEOTIDASE, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Authors: | Knoefel, T, Straeter, N. | Deposit date: | 2000-12-13 | Release date: | 2002-03-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures. J.Mol.Biol., 309, 2001
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1IT6
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![BU of 1it6 by Molmil](/molmil-images/mine/1it6) | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CALYCULIN A AND THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 1 | Descriptor: | CALYCULIN A, MANGANESE (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE 1 GAMMA (PP1-GAMMA) CATALYTIC SUBUNIT | Authors: | Kita, A, Matsunaga, S, Takai, A, Kataiwa, H, Wakimoto, T, Fusetani, N, Isobe, M, Miki, K. | Deposit date: | 2002-01-09 | Release date: | 2002-05-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1. Structure, 10, 2002
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8TWI
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![BU of 8twi by Molmil](/molmil-images/mine/8twi) | Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-21 | Release date: | 2023-11-01 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8TWE
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![BU of 8twe by Molmil](/molmil-images/mine/8twe) | Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body | Descriptor: | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-21 | Release date: | 2023-11-01 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8TTB
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![BU of 8ttb by Molmil](/molmil-images/mine/8ttb) | Cryo-EM structure of the PP2A:B55-ARPP19 complex | Descriptor: | FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-13 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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5UI1
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![BU of 5ui1 by Molmil](/molmil-images/mine/5ui1) | Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor | Descriptor: | 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | Authors: | Chattopadhyay, D, Swingle, M.R, Salter, E.A, Banerjee, S, Honkanen, R.E. | Deposit date: | 2017-01-12 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal Structure Human PP5C in Complex with an Inhibitor To Be Published
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8U5G
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![BU of 8u5g by Molmil](/molmil-images/mine/8u5g) | Crystal structure of the co-expressed SDS22:PP1:I3 complex | Descriptor: | E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2023-09-12 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange. J.Biol.Chem., 300, 2023
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4I5L
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![BU of 4i5l by Molmil](/molmil-images/mine/4i5l) | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ... | Authors: | Wlodarchak, N, Satyshur, K.A, Guo, F, Xing, Y. | Deposit date: | 2012-11-28 | Release date: | 2013-05-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res., 23, 2013
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7SOY
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![BU of 7soy by Molmil](/molmil-images/mine/7soy) | The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex | Descriptor: | Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. | Deposit date: | 2021-11-01 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition. Elife, 11, 2022
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7T0Y
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![BU of 7t0y by Molmil](/molmil-images/mine/7t0y) | The Ribosomal RNA Processing 1B Protein Phosphatase-1 Holoenzyme | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, FLUORIDE ION, ... | Authors: | Srivastava, G, Page, R, Peti, W. | Deposit date: | 2021-11-30 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs. Cell Rep, 41, 2022
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5UKI
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8W6P
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![BU of 8w6p by Molmil](/molmil-images/mine/8w6p) | Crystal structure of dimeric murine SMPDL3A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | Authors: | Zhang, C, Liu, P, Fan, S, Hou, Y. | Deposit date: | 2023-08-29 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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8W6R
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![BU of 8w6r by Molmil](/molmil-images/mine/8w6r) | murine SMPDL3A bound to sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | Authors: | Zhang, C, Liu, P, Fan, S. | Deposit date: | 2023-08-29 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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5W0W
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![BU of 5w0w by Molmil](/molmil-images/mine/5w0w) | Crystal structure of Protein Phosphatase 2A bound to TIPRL | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... | Authors: | Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. | Deposit date: | 2017-06-01 | Release date: | 2018-01-17 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Methylation-regulated decommissioning of multimeric PP2A complexes. Nat Commun, 8, 2017
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4JA7
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![BU of 4ja7 by Molmil](/molmil-images/mine/4ja7) | Rat PP5 co-crystallized with P5SA-2 | Descriptor: | MAGNESIUM ION, Serine/threonine-protein phosphatase 5 | Authors: | Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K. | Deposit date: | 2013-02-18 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci.Rep., 35, 2015
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4JA9
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![BU of 4ja9 by Molmil](/molmil-images/mine/4ja9) | Rat PP5 apo | Descriptor: | MAGNESIUM ION, Serine/threonine-protein phosphatase 5 | Authors: | Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K. | Deposit date: | 2013-02-18 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci.Rep., 35, 2015
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2NYL
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![BU of 2nyl by Molmil](/molmil-images/mine/2nyl) | Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated | Descriptor: | MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ... | Authors: | Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y. | Deposit date: | 2006-11-20 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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4KBP
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![BU of 4kbp by Molmil](/molmil-images/mine/4kbp) | KIDNEY BEAN PURPLE ACID PHOSPHATASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PHOSPHATE ION, ... | Authors: | Klabunde, T, Strater, N, Krebs, B. | Deposit date: | 1995-10-02 | Release date: | 1996-12-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures. J.Mol.Biol., 259, 1996
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2O8G
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![BU of 2o8g by Molmil](/molmil-images/mine/2o8g) | Rat pp1c gamma complexed with mouse inhibitor-2 | Descriptor: | MANGANESE (II) ION, Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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2O8A
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![BU of 2o8a by Molmil](/molmil-images/mine/2o8a) | rat PP1cgamma complexed with mouse inhibitor-2 | Descriptor: | Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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