6PKJ
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![BU of 6pkj by Molmil](/molmil-images/mine/6pkj) | MicroED structure of proteinase K from an uncoated, single lamella at 2.17A resolution (#2) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (2.176 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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6PKO
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![BU of 6pko by Molmil](/molmil-images/mine/6pko) | MicroED structure of proteinase K from a platinum coated, unpolished, single lamella at 2.07A resolution (#12) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (2.07 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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6PKR
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![BU of 6pkr by Molmil](/molmil-images/mine/6pkr) | MicroED structure of proteinase K from a platinum-coated, polished, single lamella at 1.79A resolution (#13) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (1.79 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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7VBI
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![BU of 7vbi by Molmil](/molmil-images/mine/7vbi) | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | Deposit date: | 2021-08-31 | Release date: | 2022-03-02 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
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6PKK
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![BU of 6pkk by Molmil](/molmil-images/mine/6pkk) | MicroED structure of proteinase K from an uncoated, single lamella at 2.18A resolution (#5) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (2.176 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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6PKP
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![BU of 6pkp by Molmil](/molmil-images/mine/6pkp) | MicroED structure of proteinase K from a platinum-coated, polished, single lamella at 1.91A resolution (#10) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (1.91 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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7VL8
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![BU of 7vl8 by Molmil](/molmil-images/mine/7vl8) | Cryo-EM structure of the Apo CCR1-Gi complex | Descriptor: | C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | Deposit date: | 2021-10-02 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VLA
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![BU of 7vla by Molmil](/molmil-images/mine/7vla) | Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex | Descriptor: | C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | Deposit date: | 2021-10-02 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VL9
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![BU of 7vl9 by Molmil](/molmil-images/mine/7vl9) | Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex | Descriptor: | C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ... | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | Deposit date: | 2021-10-02 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
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7VBH
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![BU of 7vbh by Molmil](/molmil-images/mine/7vbh) | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | Deposit date: | 2021-08-31 | Release date: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
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6T64
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![BU of 6t64 by Molmil](/molmil-images/mine/6t64) | A model of the EIAV CA-SP hexamer (C6) from Gag-deltaMA spheres assembled at pH6 | Descriptor: | Gag polyprotein | Authors: | Dick, R.A, Xu, C, Morado, D.R, Kravchuk, V, Ricana, C.L, Lyddon, T.D, Broad, A.M, Feathers, J.R, Johnson, M.C, Vogt, V.M, Perilla, J.R, Briggs, J.A.G, Schur, F.K.M. | Deposit date: | 2019-10-17 | Release date: | 2020-01-15 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly. Plos Pathog., 16, 2020
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7JL2
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![BU of 7jl2 by Molmil](/molmil-images/mine/7jl2) | Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Kato, K, Ahmad, S, Hur, S. | Deposit date: | 2020-07-29 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81, 2021
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7XK2
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![BU of 7xk2 by Molmil](/molmil-images/mine/7xk2) | Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | Deposit date: | 2022-04-19 | Release date: | 2023-02-22 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7TYZ
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![BU of 7tyz by Molmil](/molmil-images/mine/7tyz) | Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DARPin FSR22, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-02-15 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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8UEV
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![BU of 8uev by Molmil](/molmil-images/mine/8uev) | In-situ complex I, Deactive class04 | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 631, 2024
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7LEY
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![BU of 7ley by Molmil](/molmil-images/mine/7ley) | Trimeric human Arginase 1 in complex with mAb5 | Descriptor: | Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ... | Authors: | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | Deposit date: | 2021-01-15 | Release date: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7T2P
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![BU of 7t2p by Molmil](/molmil-images/mine/7t2p) | |
7TPI
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![BU of 7tpi by Molmil](/molmil-images/mine/7tpi) | SARS-CoV-2 E406W mutant Spike ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Addetia, A, Veesler, D. | Deposit date: | 2022-01-25 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | SARS-CoV-2 E406W mutant Spike ectodomain To Be Published
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7K01
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![BU of 7k01 by Molmil](/molmil-images/mine/7k01) | Structure of TFIIH in TFIIH/Rad4-Rad23-Rad33 DNA opening complex | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, General transcription and DNA repair factor IIH subunit SSL1, ... | Authors: | van Eeuwen, T, Min, J.H, Murakami, K. | Deposit date: | 2020-09-02 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun, 12, 2021
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7WIG
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![BU of 7wig by Molmil](/molmil-images/mine/7wig) | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | Deposit date: | 2022-01-03 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7WIC
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![BU of 7wic by Molmil](/molmil-images/mine/7wic) | Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | Deposit date: | 2022-01-03 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7Y12
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![BU of 7y12 by Molmil](/molmil-images/mine/7y12) | Cryo-EM structure of MrgD-Gi complex with beta-alanine | Descriptor: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7WZ4
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![BU of 7wz4 by Molmil](/molmil-images/mine/7wz4) | Structure of an orphan GPCR-G protein signaling complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Xu, J, Chen, G, Liu, Z, Du, Y. | Deposit date: | 2022-02-17 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun, 13, 2022
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7WU9
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![BU of 7wu9 by Molmil](/molmil-images/mine/7wu9) | Cryo-EM structure of the human EP3-Gi signaling complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T. | Deposit date: | 2022-02-07 | Release date: | 2022-08-17 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.375 Å) | Cite: | Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex. Cell Rep, 40, 2022
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7Y15
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![BU of 7y15 by Molmil](/molmil-images/mine/7y15) | Cryo-EM structure of apo-state MrgD-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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