2MYG
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![BU of 2myg by Molmil](/molmil-images/mine/2myg) | Solution structure of the dithiolic glutaredoxin 2-C-Grx1 from the pathogen Trypanosoma brucei brucei | Descriptor: | Dithiol glutaredoxin 1 | Authors: | Sturlese, M, Stefani, M, Manta, B, Mammi, S, Comini, M, Bellanda, M. | Deposit date: | 2015-01-22 | Release date: | 2016-02-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the dithiolic glutaredoxin 2-C-Grx1 from the pathogen Trypanosoma brucei brucei To be Published
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7T5Q
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![BU of 7t5q by Molmil](/molmil-images/mine/7t5q) | Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Rebowski, G, van Eeuwen, T, Boczkowska, M, Dominguez, R. | Deposit date: | 2021-12-13 | Release date: | 2023-06-14 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of an Arp2/3 complex mini-branch capped by capping protein (CapZ) To Be Published
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2N0O
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![BU of 2n0o by Molmil](/molmil-images/mine/2n0o) | |
2MWL
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![BU of 2mwl by Molmil](/molmil-images/mine/2mwl) | |
7LXD
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![BU of 7lxd by Molmil](/molmil-images/mine/7lxd) | Structure of yeast DNA Polymerase Zeta (apo) | Descriptor: | DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ... | Authors: | Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R. | Deposit date: | 2021-03-03 | Release date: | 2021-06-30 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta. J.Biol.Chem., 297, 2021
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6HCY
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![BU of 6hcy by Molmil](/molmil-images/mine/6hcy) | human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA. | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Oosterheert, W, van Bezouwen, L.S, Rodenburg, R.N.P, Forster, F, Mattevi, A, Gros, P. | Deposit date: | 2018-08-17 | Release date: | 2018-10-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction. Nat Commun, 9, 2018
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8A3B
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![BU of 8a3b by Molmil](/molmil-images/mine/8a3b) | |
8DFM
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![BU of 8dfm by Molmil](/molmil-images/mine/8dfm) | Ectodomain of full-length wild-type KIT-SCF dimers | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | Authors: | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | Deposit date: | 2022-06-22 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DFQ
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![BU of 8dfq by Molmil](/molmil-images/mine/8dfq) | Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | Authors: | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | Deposit date: | 2022-06-22 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DFP
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![BU of 8dfp by Molmil](/molmil-images/mine/8dfp) | Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | Authors: | Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J. | Deposit date: | 2022-06-22 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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8CUD
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![BU of 8cud by Molmil](/molmil-images/mine/8cud) | |
8CUJ
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![BU of 8cuj by Molmil](/molmil-images/mine/8cuj) | |
8CV3
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8CV2
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![BU of 8cv2 by Molmil](/molmil-images/mine/8cv2) | |
8CUI
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8CUA
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7LAS
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![BU of 7las by Molmil](/molmil-images/mine/7las) | Cryo-EM structure of PCV2 Replicase bound to ssDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent helicase Rep, DNA (5'-D(P*GP*AP*TP*CP*GP*AP*TP*CP*GP*A)-3'), ... | Authors: | Khayat, R. | Deposit date: | 2021-01-06 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus. Mbio, 12, 2021
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7LAR
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![BU of 7lar by Molmil](/molmil-images/mine/7lar) | Cryo-EM structure of PCV2 Replicase bound to ssDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent helicase Rep, DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Khayat, R. | Deposit date: | 2021-01-06 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus. Mbio, 12, 2021
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8AYY
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![BU of 8ayy by Molmil](/molmil-images/mine/8ayy) | Poliovirus type 3 (strain Saukett) stabilised virus-like particle (PV3 SC8) in complex with GSH and Pleconaril | Descriptor: | 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, Capsid protein, VP0, ... | Authors: | Bahar, M.W, Fry, E.E, Stuart, D.I. | Deposit date: | 2022-09-04 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation. Commun Biol, 5, 2022
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8AYX
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![BU of 8ayx by Molmil](/molmil-images/mine/8ayx) | Poliovirus type 3 (strain Saukett) stabilised virus-like particle (PV3 SC8) in complex with GSH and GPP3 | Descriptor: | 1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE, Capsid protein, VP0, ... | Authors: | Bahar, M.W, Fry, E.E, Stuart, D.I. | Deposit date: | 2022-09-04 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation. Commun Biol, 5, 2022
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8DP5
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![BU of 8dp5 by Molmil](/molmil-images/mine/8dp5) | Structure of the PEAK3/14-3-3 complex | Descriptor: | 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... | Authors: | Torosyan, H, Paul, M, Jura, N, Verba, K.A. | Deposit date: | 2022-07-14 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
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5LHT
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![BU of 5lht by Molmil](/molmil-images/mine/5lht) | ATP Phosphoribosyltransferase from Mycobacterium tuberculosis in complex with the allosteric activator 3-(2-Thienyl)-L-alanine | Descriptor: | ATP phosphoribosyltransferase, BETA(2-THIENYL)ALANINE, GLYCEROL, ... | Authors: | de Chiara, C, Pisco, J.P, de Carvalho, L.P, Smerdon, S.J, Walker, P.A, Ogrodowicz, R. | Deposit date: | 2016-07-12 | Release date: | 2017-07-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.0601 Å) | Cite: | Uncoupling conformational states from activity in an allosteric enzyme. Nat Commun, 8, 2017
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5LRE
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![BU of 5lre by Molmil](/molmil-images/mine/5lre) | Crystal structure of Glycogen Phosphorylase b in complex with KS382 | Descriptor: | (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(3-naphthalen-2-yl-1~{H}-1,2,4-triazol-5-yl)oxane-3,4,5-triol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | Authors: | Kantsadi, A.L, Stravodimos, G.A, Kyriakis, E, Chatzileontiadou, D.S.M, Leonidas, D.D. | Deposit date: | 2016-08-18 | Release date: | 2017-05-31 | Last modified: | 2018-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synthetic, enzyme kinetic, and protein crystallographic studies of C-beta-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase. Eur J Med Chem, 123, 2016
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5LRD
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![BU of 5lrd by Molmil](/molmil-images/mine/5lrd) | Crystal structure of Glycogen Phosphorylase b in complex with KS242 | Descriptor: | (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-[5-(4-methylphenyl)-4~{H}-1,2,4-triazol-3-yl]oxane-3,4,5-triol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | Authors: | Kantsadi, A.L, Leonidas, D.D. | Deposit date: | 2016-08-18 | Release date: | 2017-06-14 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | van der Waals interactions govern C-beta-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase. J. Struct. Biol., 199, 2017
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5LRF
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![BU of 5lrf by Molmil](/molmil-images/mine/5lrf) | Crystal structure of Glycogen Phosphorylase b in complex with KS389 | Descriptor: | (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(3-naphthalen-2-yl-1~{H}-1,2,4-triazol-5-yl)oxane-3,4,5-triol, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | Authors: | Kantsadi, A.L, Leonidas, D.D. | Deposit date: | 2016-08-18 | Release date: | 2017-06-14 | Last modified: | 2019-02-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | van der Waals interactions govern C-beta-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase. J. Struct. Biol., 199, 2017
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