8SFH
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8SFR
| WT CRISPR-Cas12a post nontarget strand cleavage. | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (34-MER), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Strohkendl, I, Taylor, D.W. | Deposit date: | 2023-04-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | WT CRISPR-Cas12a post nontarget strand cleavage. To Be Published
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4GGG
| Crystal structure of V66A/L68V CzrA in the Zn(II)bound state. | Descriptor: | CHLORIDE ION, Repressor protein, ZINC ION | Authors: | Campanello, G.C, Ma, Z, Grossoehme, N.E, Chakrovorty, D.K, Guerra, A.J, Ye, Y, Dann III, C.E, Merz Jr, K.M, Giedroc, D.P. | Deposit date: | 2012-08-06 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family. J.Mol.Biol., 425, 2013
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6UE5
| Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide | Descriptor: | 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | Authors: | Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E. | Deposit date: | 2019-09-20 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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8EIL
| C-Terminal Domain of BrxL from Acinetobacter BREX type I phage restriction system | Descriptor: | MALONIC ACID, Protease Lon-related BREX system protein BrxL, SUCCINIC ACID | Authors: | Doyle, L.A, Stoddard, B.L, Kaiser, B. | Deposit date: | 2022-09-15 | Release date: | 2023-02-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor. Nucleic Acids Res., 51, 2023
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1IA8
| THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1 | Descriptor: | CHK1 CHECKPOINT KINASE, SULFATE ION | Authors: | Chen, P, Luo, C, Deng, Y, Ryan, K, Register, J, Margosiak, S, Tempczyk-Russell, A, Nguyen, B, Myers, P, Lundgren, K, Chen Kan, C.-C, O'Connor, P.M. | Deposit date: | 2001-03-22 | Release date: | 2001-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell(Cambridge,Mass.), 100, 2000
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6C9T
| Transcriptional repressor, CouR | Descriptor: | CouR | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-01-28 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris. J. Biol. Chem., 293, 2018
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4MM2
| Crystal structure of yeast primase catalytic subunit | Descriptor: | CADMIUM ION, CITRIC ACID, DNA primase small subunit | Authors: | Park, K.R, An, J.Y, Lee, Y, Youn, H.S, Lee, J.G, Kang, J.Y, Kim, T.G, Lim, J.J, Eom, S.H, Wang, J. | Deposit date: | 2013-09-07 | Release date: | 2014-09-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of yeast primase catalytic subunit To be Published
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6C28
| Transcriptional repressor, CouR, bound to p-coumaroyl-CoA | Descriptor: | Transcriptional regulator, MarR family, p-coumaroyl-CoA | Authors: | Cogan, D.P, Nair, S.K. | Deposit date: | 2018-01-07 | Release date: | 2018-05-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris. J. Biol. Chem., 293, 2018
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6VMI
| Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII) | Descriptor: | 12s rRNA, 16s rRNA, 28S ribosomal protein S10, ... | Authors: | Sharma, M.R, Koripella, R.K, Agrawal, R.K. | Deposit date: | 2020-01-28 | Release date: | 2020-08-05 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation. Nat Commun, 11, 2020
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8RGG
| Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1. | Descriptor: | Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Dynein light chain 1, ... | Authors: | Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Mladenov, M, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J. | Deposit date: | 2023-12-13 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport. Embo J., 43, 2024
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5JRJ
| Crystal Structure of Herbaspirillum seropedicae RecA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Leite, W.C, Galvao, C.W, Saab, S.C, Iulek, J, Etto, R.M, Steffens, M.B.R, Chitteni-Pattu, S, Stanage, T, Keck, J.L, Cox, M.M. | Deposit date: | 2016-05-06 | Release date: | 2016-08-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament. PLoS ONE, 11, 2016
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4CYD
| GlxR bound to cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, PROBABLE EXPRESSION TAG, ... | Authors: | Townsend, P.D, Bott, M, Cann, M.J, Pohl, E. | Deposit date: | 2014-04-10 | Release date: | 2014-12-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The Crystal Structures of Apo and Camp-Bound Glxr from Corynebacterium Glutamicum Reveal Structural and Dynamic Changes Upon Camp Binding in Crp/Fnr Family Transcription Factors. Plos One, 9, 2014
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6QW2
| The Transcriptional Regulator PrfA-A218G mutant from Listeria Monocytogenes | Descriptor: | ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, SODIUM ION | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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6QVY
| The Transcriptional Regulator PrfA-A94V mutant from Listeria Monocytogenes | Descriptor: | ISOPROPYL ALCOHOL, Listeriolysin regulatory protein, SODIUM ION | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.686 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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7CGY
| Human DMC1 Q244M mutant of the post-synaptic complexes | Descriptor: | CALCIUM ION, Meiotic recombination protein DMC1/LIM15 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | Deposit date: | 2020-07-03 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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1K83
| Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin | Descriptor: | ALPHA AMANITIN, DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE, ... | Authors: | Bushnell, D.A, Cramer, P, Kornberg, R.D. | Deposit date: | 2001-10-22 | Release date: | 2002-02-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis of Transcription: Alpha-Amanitin-RNA Polymerase II Cocrystal at 2.8 A Resolution. Proc.Natl.Acad.Sci.USA, 99, 2002
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3G56
| Structure of the macrolide biosensor protein, MphR(A) | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Regulator of macrolide 2'-phosphotransferase I | Authors: | Zheng, J, Sagar, V, Smolinsky, A, Bourke, C, LaRonde-LeBlanc, N, Cropp, T.A. | Deposit date: | 2009-02-04 | Release date: | 2009-03-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin J.Mol.Biol., 387, 2009
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3FRQ
| Structure of the macrolide biosensor protein, MphR(A), with erythromcyin | Descriptor: | CHLORIDE ION, ERYTHROMYCIN A, GLYCEROL, ... | Authors: | Zheng, J, Sagar, V, Smolinsky, A, Bourke, C, LaRonde-LeBlanc, N, Cropp, T.A. | Deposit date: | 2009-01-08 | Release date: | 2009-03-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin J.Mol.Biol., 387, 2009
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7ML3
| General transcription factor TFIIH (weak binding) | Descriptor: | BJ4_G0050160.mRNA.1.CDS.1, General transcription and DNA repair factor IIH, General transcription and DNA repair factor IIH helicase subunit XPB, ... | Authors: | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | Deposit date: | 2021-04-27 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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4OAZ
| BldD CTD-c-di-GMP complex | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative DNA-binding protein | Authors: | Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G. | Deposit date: | 2014-01-06 | Release date: | 2014-11-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
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4EGZ
| Crystal Structure of AraR(DBD) in complex with operator ORR3 | Descriptor: | 5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*CP*CP*GP*TP*AP*TP*AP*CP*AP*TP*TP*TP*T)-3', 5'-D(*TP*AP*AP*AP*AP*TP*GP*TP*AP*TP*AP*CP*GP*GP*AP*CP*AP*AP*AP*TP*T)-3', ACETATE ION, ... | Authors: | Jain, D, Nair, D.T. | Deposit date: | 2012-04-02 | Release date: | 2013-02-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators. Nucleic Acids Res., 41, 2013
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2FEZ
| Mycobacterium tuberculosis EmbR | Descriptor: | Probable regulatory protein embR | Authors: | Futterer, K, Alderwick, L.J, Besra, G.S. | Deposit date: | 2005-12-17 | Release date: | 2006-01-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis Proc.Natl.Acad.Sci.Usa, 103, 2006
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8SFL
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4WSN
| Crystal structure of the COP9 signalosome, a P1 crystal form | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | Authors: | Bunker, R.D, Lingaraju, G.M, Thoma, N.H. | Deposit date: | 2014-10-28 | Release date: | 2015-12-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (5.5 Å) | Cite: | Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature, 531, 2016
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