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1FU6	NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT Authors: Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. Deposit date: 2000-09-14 Release date: 2001-02-21 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
1FYR	DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE Authors: Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C. Deposit date: 2000-10-03 Release date: 2000-12-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex. Biochemistry, 39, 2000
1GHU	NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures Descriptor: GRB2 Authors: Thornton, K.H, Mueller, W.T, Mcconnell, P, Zhu, G, Saltiel, A.R, Thanabal, V. Deposit date: 1996-08-05 Release date: 1997-01-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry, 35, 1996
1HCS	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1HCT	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1F2F	SRC SH2 THREF1TRP MUTANT Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. Deposit date: 2000-05-24 Release date: 2000-07-06 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
1IJR	Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic Descriptor: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK Authors: Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. Deposit date: 2001-04-27 Release date: 2002-05-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide Descriptor: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase Authors: Lubman, O.Y, Waksman, G. Deposit date: 2001-11-07 Release date: 2002-04-17 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-10-10 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1LKK	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) Descriptor: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1I3Z	MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE Descriptor: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE Authors: Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. Deposit date: 2001-02-19 Release date: 2003-04-08 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Eur.J.Biochem., 20, 2001
1JYU	Xray Structure of Grb2 SH2 Domain Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor Descriptor: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC Authors: Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. Deposit date: 2001-11-02 Release date: 2002-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1M61	Crystal structure of the apo SH2 domains of ZAP-70 Descriptor: PHOSPHATE ION, TYROSINE-PROTEIN KINASE ZAP-70 Authors: Folmer, R.H.A, Geschwindner, S, Xue, Y. Deposit date: 2002-07-11 Release date: 2003-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem Biochemistry, 41, 2002
1LUM	NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
2JYQ	NMR structure of the apo v-Src SH2 domain Descriptor: Tyrosine-protein kinase transforming protein Src Authors: Taylor, J.D, Ababou, A, Williams, M.A, Ladbury, J.E. Deposit date: 2007-12-17 Release date: 2008-06-24 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design Proteins, 73, 2008

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