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8ID1
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BU of 8id1 by Molmil
Crystal structure of N-Methyl-cis-4-hydroxy-L-proline dehydratase in Intestinibacter bartlettii
Descriptor: (2S,4S)-1-methyl-4-oxidanyl-pyrrolidine-2-carboxylic acid, Formate C-acetyltransferase
Authors:Jiang, L, Zhang, Y.
Deposit date:2023-02-11
Release date:2024-03-27
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.115 Å)
Cite:Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers of N-Methyl-4-hydroxyproline
Acs Catalysis, 14, 2024
5ID1
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BU of 5id1 by Molmil
Cetuximab Fab in complex with MPT-Cys meditope
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ...
Authors:Bzymek, K.P, Williams, J.C.
Deposit date:2016-02-23
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
3ID1
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BU of 3id1 by Molmil
Crystal Structure of RseP PDZ1 domain
Descriptor: Regulator of sigma E protease
Authors:Li, X, Wang, B, Feng, L, Wang, J, Shi, Y.
Deposit date:2009-07-20
Release date:2009-08-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage
Proc.Natl.Acad.Sci.USA, 106, 2009
4ID1
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BU of 4id1 by Molmil
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Gag-Pol polyprotein, SULFATE ION
Authors:Feng, L, Kvaratskhelia, M.
Deposit date:2012-12-11
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Proc.Natl.Acad.Sci.USA, 110, 2013
2ID1
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BU of 2id1 by Molmil
X-Ray Crystal Structure of Protein CV0518 from Chromobacterium violaceum, Northeast Structural Genomics Consortium Target CvR5.
Descriptor: Hypothetical protein, IODIDE ION
Authors:Forouhar, F, Zhou, W, Seetharaman, J, Ho, C.K, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-09-13
Release date:2006-09-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:

1ID1
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BU of 1id1 by Molmil
CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL
Descriptor: PUTATIVE POTASSIUM CHANNEL PROTEIN
Authors:Jiang, Y, Pico, A, Cadene, M, Chait, B.T, MacKinnon, R.
Deposit date:2001-04-02
Release date:2001-04-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.
Neuron, 29, 2001
6N6X
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BU of 6n6x by Molmil
OXA-23 mutant F110A/M221A neutral pH form imipenem complex
Descriptor: Beta-lactamase oxa23, Imipenem, SULFATE ION
Authors:Smith, C.A, Vakulenko, S.B.
Deposit date:2018-11-27
Release date:2018-12-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.
Antimicrob. Agents Chemother., 63, 2019
8C0J
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BU of 8c0j by Molmil
Structure of AmiB enzymatic domain bound to the EnvC LytM domain
Descriptor: Murein hydrolase activator EnvC, N-acetylmuramoyl-L-alanine amidase, PHOSPHATE ION, ...
Authors:Crow, A.
Deposit date:2022-12-17
Release date:2023-06-14
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (3.381 Å)
Cite:Activator-induced conformational changes regulate division-associated peptidoglycan amidases.
Proc.Natl.Acad.Sci.USA, 120, 2023
6KSP
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BU of 6ksp by Molmil
Rat GluD1 receptor(splayed conformation) in complex with 7-CKA and Calcium ions
Descriptor: Glutamate receptor ionotropic, delta-1
Authors:Burada, A.P, Kumar, J.
Deposit date:2019-08-24
Release date:2020-01-15
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture.
Nat.Struct.Mol.Biol., 27, 2020
6KSS
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BU of 6kss by Molmil
Rat GluD1 receptor(compact conformation) in complex with 7-CKA and Calcium ions
Descriptor: Glutamate receptor ionotropic, delta-1
Authors:Burada, A.P, Kumar, J.
Deposit date:2019-08-26
Release date:2020-01-15
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture.
Nat.Struct.Mol.Biol., 27, 2020
8BN2
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BU of 8bn2 by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with D-Serine
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-11
Release date:2023-11-22
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
8BN5
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BU of 8bn5 by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with GABA
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-12
Release date:2023-11-22
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
8BLJ
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BU of 8blj by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1), apo state
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-09
Release date:2023-11-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
6W35
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BU of 6w35 by Molmil
A new Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-fluoranyl-~{N}-[(2~{R})-1-[1-(2~{H}-indazol-5-yl)-3-methyl-2,4-bis(oxidanylidene)-1,3,8-triazaspiro[4.5]decan-8-yl]-3-methyl-1-oxidanylidene-butan-2-yl]-5-(trifluoromethyl)benzamide, CALCIUM ION, ...
Authors:Cuozzo, J.W.
Deposit date:2020-03-09
Release date:2020-07-08
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.
J.Med.Chem., 63, 2020
7Z2R
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BU of 7z2r by Molmil
Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics
Descriptor: Glutamate receptor ionotropic, delta-1, SULFATE ION
Authors:Masternak, M, Laulumaa, S, Kastrup, J.S.
Deposit date:2022-02-28
Release date:2023-01-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.574 Å)
Cite:Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics.
Febs J., 290, 2023
6JTB
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BU of 6jtb by Molmil
Crystal structure of dipeptidyl peptidase 11 (DPP11) with citrate from Porphyromonas gingivalis (Space)
Descriptor: Asp/Glu-specific dipeptidyl-peptidase, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Sakamoto, Y, Suzuki, Y, Iizuka, I, Roppongi, S, Kushibiki, C, Nakamura, A, Ogasawara, W, Tanaka, N.
Deposit date:2019-04-10
Release date:2019-10-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase.
Sci Rep, 9, 2019
6JTC
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BU of 6jtc by Molmil
Crystal structure of dipeptidyl peptidase 11 (DPP11) with SH-5 from Porphyromonas gingivalis (Space)
Descriptor: 2-(2-azanylethylamino)-5-nitro-benzoic acid, Asp/Glu-specific dipeptidyl-peptidase, GLYCEROL
Authors:Sakamoto, Y, Suzuki, Y, Iizuka, I, Roppongi, S, Kushibiki, C, Nakamura, A, Ogasawara, W, Tanaka, N.
Deposit date:2019-04-10
Release date:2019-10-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase.
Sci Rep, 9, 2019
5OI3
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BU of 5oi3 by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: Integrase, MAGNESIUM ION
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
6FL9
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BU of 6fl9 by Molmil
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - Wild type 2.3 Angstrom resolution
Descriptor: Cys-loop ligand-gated ion channel, TETRAETHYLENE GLYCOL, nonyl beta-D-glucopyranoside
Authors:Hu, H, Delarue, M.
Deposit date:2018-01-25
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FLI
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BU of 6fli by Molmil
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - Co-crystallization with 4-bromo cinnamic acid
Descriptor: 3-(4-bromophenyl)propanoic acid, Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside
Authors:Hu, H, Delarue, M.
Deposit date:2018-01-26
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FVR
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BU of 6fvr by Molmil
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - sTeLIC in complex with Cesium ions (Cs+)
Descriptor: CESIUM ION, Cys-loop ligand-gated ion channel, nonyl beta-D-glucopyranoside
Authors:Hu, H, Delarue, M.
Deposit date:2018-03-05
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FVS
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BU of 6fvs by Molmil
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - sTeLIC in complex with Barium ions (Ba2+)
Descriptor: BARIUM ION, Cys-loop ligand-gated ion channel, ZINC ION, ...
Authors:Hu, H, Delarue, M.
Deposit date:2018-03-05
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FVQ
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BU of 6fvq by Molmil
The active form of a pentameric ion channel (sTeLIC) gated by alkaline pH - R86A
Descriptor: Cys-loop ligand-gated ion channel, TETRAETHYLENE GLYCOL, nonyl beta-D-glucopyranoside
Authors:Hu, H, Delarue, M.
Deposit date:2018-03-05
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4NY1
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BU of 4ny1 by Molmil
X-ray structure of the unliganded uridine phosphorylase from Yersinia pseudotuberculosis at 1.7 A resolution
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
Authors:Balaev, V.V, Gabdoulkhakov, A.G, Lashkov, A.A, Mikhailov, A.M.
Deposit date:2013-12-10
Release date:2015-01-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-ray structure of the unliganded uridine phosphorylase from Yersinia pseudotuberculosis at 1.7 A resolution
TO BE PUBLISHED
5KC9
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BU of 5kc9 by Molmil
Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-1 (GluD1)
Descriptor: 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Elegheert, J, Clay, J.E, Siebold, C, Aricescu, A.R.
Deposit date:2016-06-05
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science, 353, 2016

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