4ID1

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor

Summary for 4ID1

Entry DOI	10.2210/pdb4id1/pdb
Related	1ITG
Descriptor	Gag-Pol polyprotein, (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	hiv integrase, ccd, dde motif, dimer interface, allosteric inhibitor, quinoline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
Total number of polymer chains	1
Total formula weight	18846.12
Authors	Feng, L.,Kvaratskhelia, M. (deposition date: 2012-12-11, release date: 2013-05-01, Last modification date: 2023-09-20)
Primary citation	Jurado, K.A.,Wang, H.,Slaughter, A.,Feng, L.,Kessl, J.J.,Koh, Y.,Wang, W.,Ballandras-Colas, A.,Patel, P.A.,Fuchs, J.R.,Kvaratskhelia, M.,Engelman, A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc.Natl.Acad.Sci.USA, 110:8690-8695, 2013 Cited by PubMed: 23610442 DOI: 10.1073/pnas.1300703110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation