5OI3
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Summary for 5OI3
Entry DOI | 10.2210/pdb5oi3/pdb |
Related | 4LH4 |
Descriptor | Integrase, MAGNESIUM ION (3 entities in total) |
Functional Keywords | hiv-1, integrase, catalytic core domain, viral protein |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Total number of polymer chains | 1 |
Total formula weight | 20103.90 |
Authors | Ruff, M.,Benarous, R. (deposition date: 2017-07-18, release date: 2018-03-07, Last modification date: 2024-01-17) |
Primary citation | Bonnard, D.,Le Rouzic, E.,Eiler, S.,Amadori, C.,Orlov, I.,Bruneau, J.M.,Brias, J.,Barbion, J.,Chevreuil, F.,Spehner, D.,Chasset, S.,Ledoussal, B.,Moreau, F.,Saib, A.,Klaholz, B.P.,Emiliani, S.,Ruff, M.,Zamborlini, A.,Benarous, R. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293:6172-6186, 2018 Cited by PubMed: 29507092DOI: 10.1074/jbc.M117.816793 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report