8X1D
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8Q3C
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![BU of 8q3c by Molmil](/molmil-images/mine/8q3c) | Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant | Descriptor: | CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ... | Authors: | Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D. | Deposit date: | 2023-08-03 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
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7B4R
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![BU of 7b4r by Molmil](/molmil-images/mine/7b4r) | Structure of the 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus in complex with Coenzyme A and N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea | Descriptor: | COENZYME A, MANGANESE (II) ION, N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea, ... | Authors: | Maveyraud, L, Carivenc, C, Blanger, C, Mourey, L. | Deposit date: | 2020-12-02 | Release date: | 2021-11-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep, 11, 2021
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8W7F
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![BU of 8w7f by Molmil](/molmil-images/mine/8w7f) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase bound with FAD and a sulfate ion | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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7B4S
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![BU of 7b4s by Molmil](/molmil-images/mine/7b4s) | Structure of the 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus in complex with Coenzyme A and compound 153786 from the NCI Open Database | Descriptor: | 5-[(4-chlorophenyl)methyl]-6-[[2-(dimethylamino)ethylamino]methyl]-4-oxidanyl-1~{H}-pyrimidine-2-thione, COENZYME A, MANGANESE (II) ION, ... | Authors: | Maveyraud, L, Carivenc, C, Mourey, L. | Deposit date: | 2020-12-02 | Release date: | 2021-11-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep, 11, 2021
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8Q2E
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![BU of 8q2e by Molmil](/molmil-images/mine/8q2e) | The 1.68-A X-ray crystal structure of Sporosarcina pasteurii urease inhibited by thiram and bound to dimethylditiocarbamate | Descriptor: | 1,2-ETHANEDIOL, HYDROXIDE ION, NICKEL (II) ION, ... | Authors: | Mazzei, L, Cianci, M, Ciurli, S. | Deposit date: | 2023-08-02 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Kinetic and structural details of urease inactivation by thiuram disulphides. J.Inorg.Biochem., 250, 2023
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7NUU
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![BU of 7nuu by Molmil](/molmil-images/mine/7nuu) | Crystal structure of human AMDHD2 in complex with Zn | Descriptor: | GLYCEROL, N-acetylglucosamine-6-phosphate deacetylase, ZINC ION | Authors: | Ruegenberg, S, Kroef, V, Baumann, U, Denzel, M.S. | Deposit date: | 2021-03-14 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.836 Å) | Cite: | GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Elife, 11, 2022
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7NUT
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![BU of 7nut by Molmil](/molmil-images/mine/7nut) | Crystal structure of human AMDHD2 in complex with Zn and GlcN6P | Descriptor: | 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, N-acetylglucosamine-6-phosphate deacetylase, ZINC ION | Authors: | Ruegenberg, S, Kroef, V, Baumann, U, Denzel, M.S. | Deposit date: | 2021-03-14 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Elife, 11, 2022
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4XFA
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4XFI
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7O81
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![BU of 7o81 by Molmil](/molmil-images/mine/7o81) | Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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4XJA
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![BU of 4xja by Molmil](/molmil-images/mine/4xja) | Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid | Descriptor: | (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, DIMETHYL SULFOXIDE, ... | Authors: | Brear, P. | Deposit date: | 2015-01-08 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
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7O7Y
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![BU of 7o7y by Molmil](/molmil-images/mine/7o7y) | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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7O80
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![BU of 7o80 by Molmil](/molmil-images/mine/7o80) | Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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4XQW
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![BU of 4xqw by Molmil](/molmil-images/mine/4xqw) | X-ray structure analysis of xylanase-N44E with MES at pH6.0 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-1,4-beta-xylanase 2, IODIDE ION | Authors: | Wan, Q, Park, J.M, Riccardi, D.M, Hanson, L.B, Fisher, Z, Smith, J.C, Ostermann, A, Schrader, T, Graham, D.E, Coates, L, Langan, P, Kovalevsky, A.Y. | Deposit date: | 2015-01-20 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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4XS3
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![BU of 4xs3 by Molmil](/molmil-images/mine/4xs3) | Crystal structure of a metabolic reductase with (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one | Descriptor: | (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zheng, B, Wu, F, Jiang, H, Kogiso, M, Yao, Y, Zhou, C, Li, X, Song, Y. | Deposit date: | 2015-01-21 | Release date: | 2016-07-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.291 Å) | Cite: | Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J.Med.Chem., 58, 2015
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8W7P
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![BU of 8w7p by Molmil](/molmil-images/mine/8w7p) | Extracellular domain of a sensor histidine kinase | Descriptor: | Extracellular domain of a sensor histidine kinase NagS, GLYCEROL | Authors: | Itoh, T, Ogawa, T, Hibi, T, Kimoto, H. | Deposit date: | 2023-08-31 | Release date: | 2024-01-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Characterization of the extracellular domain of sensor histidine kinase NagS from Paenibacillus sp. str. FPU-7: nagS interacts with oligosaccharide binding protein NagB1 in complexes with N, N'-diacetylchitobiose. Biosci.Biotechnol.Biochem., 88, 2024
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8VJ3
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8X2L
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4XAF
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![BU of 4xaf by Molmil](/molmil-images/mine/4xaf) | Cycles of destabilization and repair underlie evolutionary transitions in enzymes | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R1, ... | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | Deposit date: | 2014-12-14 | Release date: | 2015-12-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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8QQS
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4XUQ
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1KTL
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![BU of 1ktl by Molmil](/molmil-images/mine/1ktl) | The human non-classical major histocompatibility complex molecule HLA-E | Descriptor: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN, ... | Authors: | Holmes, M.A, Strong, R.K. | Deposit date: | 2002-01-16 | Release date: | 2003-02-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | HLA-E allelic variants: Correlating differential expression, peptide affinities, crystal structures and thermal stabilities J.Biol.Chem., 278, 2003
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4XWR
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4XX6
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![BU of 4xx6 by Molmil](/molmil-images/mine/4xx6) | Crystal structure of a glycosylated endo-beta-1,4-xylanase (glycoside hydrolase family 10/GH10) enzyme from Gloeophyllum trabeum | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-xylanase, ... | Authors: | Stogios, P.J, Nocek, B, Xu, X, Cui, H, Lowden, M, Savchenko, A. | Deposit date: | 2015-01-29 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of a glycosylated endo-beta-1,4-xylanase (glycoside hydrolase family 10/GH10) enzyme from Gloeophyllum trabeum. To Be Published
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