4XAF

Cycles of destabilization and repair underlie evolutionary transitions in enzymes

Summary for 4XAF

Entry DOI	10.2210/pdb4xaf/pdb
Related	4PBE 4PBF 4PCN 4PCP 4XAG 4XAY 4XAZ 4XD3 4XD4 4XD5 4XD6
Descriptor	Phosphotriesterase variant PTE-R1, ZINC ION, CACODYLATE ION, ... (5 entities in total)
Functional Keywords	dynamics, evolution, phosphotriesterase, hydrolase
Biological source	Brevundimonas diminuta
Total number of polymer chains	2
Total formula weight	72922.32
Authors	Jackson, C.J.,Campbell, E.,Kaltenbach, M.,Tokuriki, N. (deposition date: 2014-12-14, release date: 2015-12-16, Last modification date: 2023-11-15)
Primary citation	Campbell, E.,Kaltenbach, M.,Correy, G.J.,Carr, P.D.,Porebski, B.T.,Livingstone, E.K.,Afriat-Jurnou, L.,Buckle, A.M.,Weik, M.,Hollfelder, F.,Tokuriki, N.,Jackson, C.J. The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12:944-950, 2016 Cited by PubMed: 27618189 DOI: 10.1038/nchembio.2175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation