8BO9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bo9 by Molmil](/molmil-images/mine/8bo9) | NanoLuc-D9R/H57A/K89R mutant complexed with azacoelenterazine bound in intra-barrel catalytic site | Descriptor: | 3-(4-hydroxyphenyl)-8-[(4-hydroxyphenyl)methyl]-5-(phenylmethyl)-1$l^{4},4,7,8-tetrazabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, Non structural polyprotein | Authors: | Marek, M, Janin, L.Y. | Deposit date: | 2022-11-15 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nat Commun, 14, 2023
|
|
7Y1J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y1j by Molmil](/molmil-images/mine/7y1j) | Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | Authors: | Chen, L, Ding, D, Hou, T. | Deposit date: | 2022-06-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
|
|
7Y1L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y1l by Molmil](/molmil-images/mine/7y1l) | Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | Authors: | Chen, L, Ding, D, Hou, T. | Deposit date: | 2022-06-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
|
|
7Y1K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y1k by Molmil](/molmil-images/mine/7y1k) | Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ... | Authors: | Chen, L, Ding, D, Hou, T. | Deposit date: | 2022-06-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
|
|
7Y1M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y1m by Molmil](/molmil-images/mine/7y1m) | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | Authors: | Chen, L, Ding, D, Hou, T. | Deposit date: | 2022-06-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
|
|
8BWF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bwf by Molmil](/molmil-images/mine/8bwf) | PTBP1 RRM1 bound to an allosteric inhibitor | Descriptor: | AMINO GROUP, GLYCEROL, Ligand, ... | Authors: | Schmeing, S, Vetter, I, t Hart, P, Gasper, R. | Deposit date: | 2022-12-06 | Release date: | 2023-10-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci, 14, 2023
|
|
7Y1N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y1n by Molmil](/molmil-images/mine/7y1n) | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | Authors: | Chen, L, Ding, D, Hou, T. | Deposit date: | 2022-06-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
|
|
7Y09
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7y09 by Molmil](/molmil-images/mine/7y09) | Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | Authors: | Shen, H, Ji, C, Xiao, J. | Deposit date: | 2022-06-03 | Release date: | 2023-03-29 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nat Commun, 14, 2023
|
|
7YG2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yg2 by Molmil](/molmil-images/mine/7yg2) | Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DBLMSP2, ... | Authors: | Shen, H, Ji, C, Xiao, J. | Deposit date: | 2022-07-09 | Release date: | 2023-03-29 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nat Commun, 14, 2023
|
|
6S5P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s5p by Molmil](/molmil-images/mine/6s5p) | Cfucosylated peptide SBL2 bound to Fucose binding Lectin LecB (PA-IIL) from Pseudomonas aeruginosa at 1.46 Angstrom resolution | Descriptor: | 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin, ... | Authors: | Baeriswyl, S, Stocker, A, Reymond, J.-L. | Deposit date: | 2019-07-02 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. Acs Chem.Biol., 14, 2019
|
|
7YEH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yeh by Molmil](/molmil-images/mine/7yeh) | Cryo-EM structure of human OGT-OGA complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein O-GlcNAcase, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, ... | Authors: | Lu, P, Liu, Y, Yu, H, Gao, H. | Deposit date: | 2022-07-05 | Release date: | 2023-07-12 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex. Nat Commun, 14, 2023
|
|
7YEA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yea by Molmil](/molmil-images/mine/7yea) | Human O-GlcNAc transferase Dimer | Descriptor: | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | Authors: | Gao, H, Lu, P, Liu, Y. | Deposit date: | 2022-07-05 | Release date: | 2023-07-12 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex. Nat Commun, 14, 2023
|
|
6R1B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6r1b by Molmil](/molmil-images/mine/6r1b) | Crystal structure of UgpB from Mycobacterium tuberculosis in complex with glycerophosphocholine | Descriptor: | 2-(((R)-2,3-DIHYDROXYPROPYL)PHOSPHORYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM, GLYCEROL, MAGNESIUM ION, ... | Authors: | Fenn, J, Nepravishta, R, Guy, C.S, Harrison, J, Angulo, J, Cameron, A.D, Fullam, E. | Deposit date: | 2019-03-14 | Release date: | 2019-09-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.27000213 Å) | Cite: | Structural Basis of Glycerophosphodiester Recognition by theMycobacterium tuberculosisSubstrate-Binding Protein UgpB. Acs Chem.Biol., 14, 2019
|
|
8BTG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btg by Molmil](/molmil-images/mine/8btg) | Cryo-EM structure of the bacterial replication origin opening basal unwinding system | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chromosomal replication initiator protein DnaA, DNA (41-MER), ... | Authors: | Pelliciari, S, Bodet-Lefevre, S, Murray, H, Ilangovan, A. | Deposit date: | 2022-11-28 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The bacterial replication origin BUS promotes nucleobase capture. Nat Commun, 14, 2023
|
|
8C50
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c50 by Molmil](/molmil-images/mine/8c50) | |
8C3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c3n by Molmil](/molmil-images/mine/8c3n) | |
8C0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c0o by Molmil](/molmil-images/mine/8c0o) | |
7Z18
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z18 by Molmil](/molmil-images/mine/7z18) | E. coli C-P lyase bound to a PhnK ABC dimer and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, ... | Authors: | Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E. | Deposit date: | 2022-02-24 | Release date: | 2022-05-25 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (1.98 Å) | Cite: | Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase. Nat Commun, 14, 2023
|
|
7Z19
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z19 by Molmil](/molmil-images/mine/7z19) | E. coli C-P lyase bound to a single PhnK ABC domain | Descriptor: | Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ... | Authors: | Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E. | Deposit date: | 2022-02-24 | Release date: | 2022-05-25 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase. Nat Commun, 14, 2023
|
|
7Z17
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z17 by Molmil](/molmil-images/mine/7z17) | E. coli C-P lyase bound to a PhnK ABC dimer in an open conformation | Descriptor: | Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ... | Authors: | Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E. | Deposit date: | 2022-02-24 | Release date: | 2022-05-25 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase. Nat Commun, 14, 2023
|
|
7YML
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yml by Molmil](/molmil-images/mine/7yml) | Structure of photosynthetic LH1-RC super-complex of Rhodobacter capsulatus | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, BACTERIOCHLOROPHYLL A, ... | Authors: | Tani, K, Kanno, R, Ji, X.-C, Satoh, I, Kobayashi, Y, Nagashima, K.V.P, Hall, M, Yu, L.-J, Kimura, Y, Mizoguchi, A, Humbel, B.M, Madigan, M.T, Wang-Otomo, Z.-Y. | Deposit date: | 2022-07-28 | Release date: | 2023-02-22 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Rhodobacter capsulatus forms a compact crescent-shaped LH1-RC photocomplex. Nat Commun, 14, 2023
|
|
7Z8E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z8e by Molmil](/molmil-images/mine/7z8e) | Crystal structure of the substrate-binding protein YejA from S. meliloti in complex with peptide fragment | Descriptor: | 1,2-ETHANEDIOL, ABC transporter substrate-binding protein, GLY-SER-ASP-VAL-ALA, ... | Authors: | Morera, S, Vigouroux, V, Travin, D.Y. | Deposit date: | 2022-03-17 | Release date: | 2023-02-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria. Mbio, 14, 2023
|
|
8CBH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cbh by Molmil](/molmil-images/mine/8cbh) | SHP2 in complex with a novel allosteric inhibitor | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11, [(1~{S},6~{R},7~{S})-3-[3-[2,3-bis(chloranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyrazin-6-yl]-7-(4-methyl-1,3-thiazol-2-yl)-3-azabicyclo[4.1.0]heptan-7-yl]methanamine | Authors: | di Fabio, R, Petrocchi, A. | Deposit date: | 2023-01-25 | Release date: | 2023-04-26 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors. Acs Med.Chem.Lett., 14, 2023
|
|
1ATI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ati by Molmil](/molmil-images/mine/1ati) | CRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS | Descriptor: | GLYCYL-TRNA SYNTHETASE, GLYCYL-tRNA SYNTHETASE | Authors: | Logan, D.T, Mazauric, M.-H, Kern, D, Moras, D. | Deposit date: | 1996-04-23 | Release date: | 1997-07-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus. EMBO J., 14, 1995
|
|
7ZS5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zs5 by Molmil](/molmil-images/mine/7zs5) | Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | Deposit date: | 2022-05-06 | Release date: | 2023-02-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun, 14, 2023
|
|