2HKE
| Mevalonate diphosphate decarboxylase from Trypanosoma brucei | Descriptor: | Diphosphomevalonate decarboxylase, putative, SULFATE ION | Authors: | Byres, E, Alphey, M.S, Hunter, W.N. | Deposit date: | 2006-07-04 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Trypanosoma brucei and Staphylococcus aureus Mevalonate Diphosphate Decarboxylase Inform on the Determinants of Specificity and Reactivity J.Mol.Biol., 371, 2007
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2HK2
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2HK3
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5MG7
| New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2) | Descriptor: | Cellular tumor antigen p53, DNA, ZINC ION | Authors: | Rozenberg, H, Braeuning, B, Golovenko, D, Shakked, Z. | Deposit date: | 2016-11-21 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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2XWR
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6NMI
| Cryo-EM structure of the human TFIIH core complex | Descriptor: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, ... | Authors: | Greber, B.J, Toso, D, Fang, J, Nogales, E. | Deposit date: | 2019-01-10 | Release date: | 2019-03-13 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The complete structure of the human TFIIH core complex. Elife, 8, 2019
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6ZNC
| Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2020-07-06 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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4Q2K
| Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b | Descriptor: | (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide, Chymotrypsinogen A | Authors: | Chan, H.Y, Bruning, J.B, Abell, A.D. | Deposit date: | 2014-04-09 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Macrocyclic protease inhibitors with reduced peptide character. Angew.Chem.Int.Ed.Engl., 53, 2014
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4VGC
| GAMMA-CHYMOTRYPSIN D-NAPHTHYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | Descriptor: | D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | Deposit date: | 1997-05-01 | Release date: | 1997-11-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
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3KMD
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3KZ8
| Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3) | Descriptor: | Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), IODIDE ION, ... | Authors: | Rozenberg, H, Suad, O, Shakked, Z. | Deposit date: | 2009-12-08 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nat.Struct.Mol.Biol., 17, 2010
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4QO1
| p53 DNA binding domain in complex with Nb139 | Descriptor: | Cellular tumor antigen p53, Nb139 Nanobody against the DNA-binding domain of p53, ZINC ION | Authors: | De Gieter, S, Bethuyne, J, Gettemans, J, Garcia-Pino, A, Loris, R. | Deposit date: | 2014-06-19 | Release date: | 2014-10-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.924 Å) | Cite: | A nanobody modulates the p53 transcriptional program without perturbing its functional architecture. Nucleic Acids Res., 42, 2014
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4XR8
| Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | Deposit date: | 2015-01-20 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
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2ADY
| Structural Basis of DNA Recognition by p53 Tetramers (complex IV) | Descriptor: | 5'-D(*CP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION | Authors: | Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z. | Deposit date: | 2005-07-21 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis of DNA Recognition by p53 Tetramers Mol.Cell, 22, 2006
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2AC0
| Structural Basis of DNA Recognition by p53 Tetramers (complex I) | Descriptor: | 5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION | Authors: | Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z. | Deposit date: | 2005-07-18 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis of DNA Recognition by p53 Tetramers Mol.Cell, 22, 2006
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6SL6
| p53 charged core | Descriptor: | Cellular tumor antigen p53, GLYCEROL, ZINC ION | Authors: | Gallardo, R, Langenberg, T, Schymkowitz, J, Rousseau, F, Ulens, C. | Deposit date: | 2019-08-18 | Release date: | 2020-03-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins. Cell Rep, 31, 2020
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6FF9
| Mutant R280K of human P53 | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Trovao, F.G, Gomes, A.S, Pinheiro, B, Carvalho, A.L, Romao, M.J. | Deposit date: | 2018-01-04 | Release date: | 2018-04-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding. Int J Mol Sci, 19, 2018
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6FJ5
| New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... | Authors: | Golovenko, D, Rozenberg, H, Shakked, Z. | Deposit date: | 2018-01-20 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.051 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5XZC
| Cryo-EM structure of p300-p53 protein complex | Descriptor: | Cellular tumor antigen p53, Histone acetyltransferase p300 | Authors: | Ghosh, R, Roy, S, Sengupta, J. | Deposit date: | 2017-07-12 | Release date: | 2019-01-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (10.7 Å) | Cite: | Tumor suppressor p53-mediated structural reorganization of the transcriptional coactivator p300. Biochemistry, 2019
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5CHA
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2ATA
| Structural Basis of DNA Recognition by p53 Tetramers (complex II) | Descriptor: | 5'-D(*AP*AP*GP*GP*CP*AP*TP*GP*CP*CP*TP*T)-3', Cellular tumor antigen p53, ZINC ION | Authors: | Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z. | Deposit date: | 2005-08-24 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of DNA Recognition by p53 Tetramers Mol.Cell, 22, 2006
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6GCH
| STRUCTURE OF CHYMOTRYPSIN-*TRIFLUOROMETHYL KETONE INHIBITOR COMPLEXES. COMPARISON OF SLOWLY AND RAPIDLY EQUILIBRATING INHIBITORS | Descriptor: | 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), GAMMA-CHYMOTRYPSIN A | Authors: | Brady, K, Wei, A, Ringe, D, Abeles, R.H. | Deposit date: | 1990-04-06 | Release date: | 1990-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors. Biochemistry, 29, 1990
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8XP5
| The Crystal Structure of p53/BCL-xL fusion complex from Biortus. | Descriptor: | Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | Deposit date: | 2024-01-03 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The Crystal Structure of p53/BCL-xL fusion complex from Biortus. To Be Published
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1YPH
| High resolution structure of bovine alpha-chymotrypsin | Descriptor: | CHYMOTRYPSIN A, chain A, chain B, ... | Authors: | Razeto, A, Galunsky, B, Kasche, V, Wilson, K.S, Lamzin, V.S. | Deposit date: | 2005-01-31 | Release date: | 2006-02-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | High resolution structure of native bovine alpha-chymotrypsin To be Published
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5ECG
| Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | Descriptor: | Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2015-10-20 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX. Cell Rep, 13, 2015
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