3KZ8

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)

Summary for 3KZ8

• Entry DOI: 10.2210/pdb3kz8/pdb
• Related: 3IGK 3IGL
• Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), ZINC ION, ... (5 entities in total)
• Functional Keywords: p53, mutant protein, loop-sheet-helix motif, dna target, activator, anti-oncogene apoptosis, cell cycle, covalent protein-rna linkage, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transcription/dna comple, apoptosis, isopeptide bond, tumor suppressor, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 3
• Total formula weight: 51836.92

Authors

Rozenberg, H.,Suad, O.,Shakked, Z. (deposition date: 2009-12-08, release date: 2010-03-31, Last modification date: 2023-11-01)

• Primary citation: Kitayner, M.,Rozenberg, H.,Rohs, R.,Suad, O.,Rabinovich, D.,Honig, B.,Shakked, Z.; Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs; Nat.Struct.Mol.Biol., 17:423-429, 2010; PubMed: 20364130; DOI: 10.1038/nsmb.1800

Experimental method

X-RAY DIFFRACTION (1.91 Å)