6FF9
Mutant R280K of human P53
Summary for 6FF9
Entry DOI | 10.2210/pdb6ff9/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION (3 entities in total) |
Functional Keywords | p53, mutant, dna binding, anticancer therapy, dna binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 4 |
Total formula weight | 87236.56 |
Authors | Trovao, F.G.,Gomes, A.S.,Pinheiro, B.,Carvalho, A.L.,Romao, M.J. (deposition date: 2018-01-04, release date: 2018-04-25, Last modification date: 2024-01-17) |
Primary citation | Gomes, A.S.,Trovao, F.,Andrade Pinheiro, B.,Freire, F.,Gomes, S.,Oliveira, C.,Domingues, L.,Romao, M.J.,Saraiva, L.,Carvalho, A.L. The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding. Int J Mol Sci, 19:-, 2018 Cited by PubMed: 29652801DOI: 10.3390/ijms19041184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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