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6HBY	HLA class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope Descriptor: 1,2-ETHANEDIOL, ARRPPLAELAALNLSGSRL 5T4 tumour epitope, HLA class II histocompatibility antigen, ... Authors: MacLachlan, B, Rizkallah, P.J, Sewell, A.K, Cole, D.K, Godkin, A.J. Deposit date: 2018-08-13 Release date: 2019-08-14 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. J.Biol.Chem., 294, 2019
7EJL	Complex Structure of HLA-A*2402 with the Peptide from HCoV(CoV-2) spike protein Descriptor: 9-mer peptide from the HCoV spike protein, Beta-2-microglobulin, MHC class I antigen Authors: Murayama, K, Kato-Murayama, M, Shirouzu, M. Deposit date: 2021-04-02 Release date: 2022-01-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2. Commun Biol, 4, 2021
7DZN	Crystal Structure of the cross-restricted T18A TCR and HLAB4201 bound to HIV-1 Gag TL9 peptide Descriptor: Beta-2-microglobulin, Gag-Pol polyprotein, MHC class I antigen, ... Authors: Liu, Y, Yin, L. Deposit date: 2021-01-25 Release date: 2022-01-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection Biorxiv, 2021
7EJN	Complex Structure of HLA-A*2402 with the Peptide from HCoV(CoV-HKU1) spike protein Descriptor: 9-mer peptide from the HCoV spike protein, Beta-2-microglobulin, MHC class I antigen Authors: Murayama, K, Kato-Murayama, M, Shirouzu, M. Deposit date: 2021-04-02 Release date: 2022-01-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2. Commun Biol, 4, 2021
6JTP	Crystal structure of HLA-C08 in complex with a tumor mut9m peptide Descriptor: 9-mer peptide, Beta-2-microglobulin, HLA class I antigen, ... Authors: Bai, P, Zhou, Q, Wei, P, Lei, Y. Deposit date: 2019-04-11 Release date: 2020-04-15 Last modified: 2021-02-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. Oncoimmunology, 10, 2021
7EJM	Complex Structure of HLA-A*2402 with the Peptide from HCoV(CoV-229E) spike protein Descriptor: 9-mer peptide from the HCoV spike protein, Beta-2-microglobulin, MHC class I antigen Authors: Murayama, K, Kato-Murayama, M, Shirouzu, M. Deposit date: 2021-04-02 Release date: 2022-01-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2. Commun Biol, 4, 2021
7DUU	Crystal structure of HLA molecule with an KIR receptor Descriptor: Beta-2-microglobulin, Killer cell immunoglobulin-like receptor 2DS2, LEU-ASN-PRO-SER-VAL-ALA-ALA-THR-LEU, ... Authors: Yang, Y, Yin, L. Deposit date: 2021-01-11 Release date: 2022-02-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor. Immunology, 165, 2022
7DZM	Crystal Structure of the cross-restricted T18A TCR and HLAB8101 bound to HIV-1 Gag TL9 peptide Descriptor: Beta-2-microglobulin, Gag-Pol polyprotein, MHC class I antigen, ... Authors: Liu, Y, Yin, L. Deposit date: 2021-01-25 Release date: 2022-01-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection Biorxiv, 2021
8DVG	Structure of KRAS WT(7-16)-HLA-A*03:01 Descriptor: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, HLA class I histocompatibility antigen, ... Authors: Wright, K.M, Miller, M, Gabelli, S.B. Deposit date: 2022-07-28 Release date: 2023-07-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.594 Å) Cite: Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nat Commun, 14, 2023
8EC5	Structures of HLA-B8E76C loaded with long peptides reveal novel features at the N-terminus of the groove Descriptor: Beta-2-microglobulin, MHC class I antigen, peptide RARARARARARAFVKKKYCL Authors: Li, L, Bouvier, M. Deposit date: 2022-09-01 Release date: 2023-07-26 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing. Nat Commun, 14, 2023
8DNT	SARS-CoV-2 specific T cell receptor Descriptor: Beta-2-microglobulin, MHC class I antigen alpha chain, Nucleoprotein, ... Authors: Gallagher, D.T, Wu, D, Gowthaman, R, Pierce, B.G, Mariuzza, R.A, Weng, N.P. Deposit date: 2022-07-11 Release date: 2023-07-19 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.18 Å) Cite: SARS-CoV-2 infection establishes a stable and age-independent CD8 + T cell response against a dominant nucleocapsid epitope using restricted T cell receptors. Nat Commun, 14, 2023
8E13	Structures of HLA-B8E76C loaded with long peptides reveal novel features at the N-terminus of the groove Descriptor: Beta-2-microglobulin, MHC class I antigen, PHE-ALA-LYS-LYS-LYS-TYR-CYS-LEU Authors: Li, L, Bouvier, M. Deposit date: 2022-08-09 Release date: 2023-07-26 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing. Nat Commun, 14, 2023
8E8I	Structures of HLA-B8E76C loaded with long peptides reveal novel features at the N-terminus of the groove Descriptor: Beta-2-microglobulin, MHC class I antigen, PHE-VAL-LYS-LYS-LYS-TYR-CYS-LEU Authors: Li, L, Bouvier, M. Deposit date: 2022-08-25 Release date: 2023-07-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing. Nat Commun, 14, 2023
6G3J	MHC A02 Allele presenting MTSAIGILVP Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... Authors: Rizkallah, P.J, Sewell, A.K. Deposit date: 2018-03-26 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Peptide Super-Agonist Enhances T-Cell Responses to Melanoma. Front Immunol, 10, 2019
8E2Z	Structures of HLA-B8E76C loaded with long peptides reveal novel features at the N-terminus of the groove Descriptor: ALA-PHE-ALA-LYS-LYS-LYS-TYR-CYS-LEU, Beta-2-microglobulin, MHC class I protein (Fragment) Authors: Li, L, Bouvier, M. Deposit date: 2022-08-16 Release date: 2023-08-02 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing. Nat Commun, 14, 2023
6G9Q	Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase. Descriptor: Beta-2-microglobulin, Dopamine beta-hydroxylase, GLYCEROL, ... Authors: Achour, A, Sandalova, T, Allerbring, E. Deposit date: 2018-04-11 Release date: 2019-04-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural basis for CD8+ T cells auto-reactivity in LCMV infection to be published
6H6H	Crystal structures of the murine class I major histocompatibility complex H-2Dbm13 in complex with adenovirus-derived peptide Ad10 Descriptor: Beta-2-microglobulin, GLYCEROL, H-2D cell surface glycoprotein, ... Authors: Achour, A, Sandalova, T, Han, X. Deposit date: 2018-07-27 Release date: 2019-08-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of H-2Db and H-2Dbm13 with cancer-associated Ad 10 peptide reveal that subtle changes in the peptide environment impact thermostability and alloreactivity to be published
7FJD	Cryo-EM structure of a membrane protein(WT) Descriptor: CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... Authors: Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. Deposit date: 2021-08-03 Release date: 2022-07-27 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
7FJE	Cryo-EM structure of a membrane protein(LL) Descriptor: CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... Authors: Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. Deposit date: 2021-08-03 Release date: 2022-07-27 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
7FJF	Cryo-EM structure of a membrane protein(CS) Descriptor: CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... Authors: Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. Deposit date: 2021-08-03 Release date: 2022-07-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
6GH1	HLA-E*01:03 in complex with Mtb44 Descriptor: Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], MHC class I antigen, ... Authors: Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. Deposit date: 2018-05-04 Release date: 2018-08-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun, 9, 2018
6GHN	HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P9-Phe. Descriptor: ARG-LEU-PRO-ALA-LYS-ALA-PRO-LEU-PHE, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... Authors: Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. Deposit date: 2018-05-08 Release date: 2018-08-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.542 Å) Cite: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun, 9, 2018
8EMA	mouse full length B cell receptor Descriptor: Anti-human Langerin 2G3 lambda chain, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... Authors: Ying, D, Xiong, P, Michael, R. Deposit date: 2022-09-27 Release date: 2022-11-16 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (8.2 Å) Cite: Structural principles of B cell antigen receptor assembly. Nature, 612, 2022
6ILG	CRYSTAL STRUCTURE OF BAT MHC CLASS I PTAL-N*01:01 FOR 2.6 ANGSTROM Descriptor: Beta-2-microglobulin, HEV-1-P8L, MHC class I antigen Authors: Qu, Z.H, Zhang, N.Z, Xia, C. Deposit date: 2018-10-18 Release date: 2019-07-24 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. J Immunol., 202, 2019
6K60	Structural and functional basis for HLA-G isoform recognition of immune checkpoint receptor LILRBs Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, alpha chain G, ... Authors: Kuroki, K, Matsubara, H, Kanda, R, Miyashita, N, Shiroishi, M, Fukunaga, Y, Kamishikiryo, J, Fukunaga, A, Hirose, K, Sugita, Y, Kita, S, Ose, T, Maenaka, K. Deposit date: 2019-05-31 Release date: 2019-11-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.149 Å) Cite: Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms. J Immunol., 203, 2019

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