PDB: 72372 resultsInfo pagesStatus searchChemie searchBIRD

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1HJC	CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER Descriptor: DNA (5'-(*GP*AP*AP*CP*TP*CP*TP*GP*TP*GP*GP* TP*TP*GP*CP*G)-3'), DNA (5'-(CP*CP*GP*CP*AP*AP*CP*CP*AP*CP*AP* GP*AP*GP*TP*T)-3'), RUNT-RELATED TRANSCRIPTION FACTOR 1 Authors: Tahirov, T.H, Ogata, K. Deposit date: 2001-01-11 Release date: 2001-03-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Analyses of DNA Recognition by the Aml1/Runx-1 Runt Domain and its Allosteric Control by Cbfbeta Cell(Cambridge,Mass.), 104, 2001
3O85	Giardia lamblia 15.5kD RNA binding protein Descriptor: Ribosomal protein L7Ae Authors: Biswas, S, Maxwell, E.S. Deposit date: 2010-08-02 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.806 Å) Cite: Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry, 50, 2011
1T4N	Solution structure of Rnt1p dsRBD Descriptor: Ribonuclease III Authors: Leulliot, N, Quevillon-Cheruel, S, Graille, M, van Tilbeurgh, H, Leeper, T.C, Godin, K.S, Edwards, T.E, Sigurdsson, S.T, Rozenkrants, N, Nagel, R.J, Ares, M, Varani, G. Deposit date: 2004-04-30 Release date: 2004-07-13 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III Embo J., 23, 2004
1T4O	Crystal structure of rnt1p dsRBD Descriptor: Ribonuclease III Authors: Leulliot, N, Quevillon-Cheruel, S, Graille, M, van Tilbeurgh, H, Leeper, T.C, Godin, K.S, Edwards, T.E, Sigurdsson, S.T, Rozenkrants, N, Nagel, R.J, Ares Jr, M, Varani, G. Deposit date: 2004-04-30 Release date: 2004-06-22 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III Embo J., 23, 2004
3D4W	Crystal structure of Staphylococcal nuclease variant Delta+PHS A109R at cryogenic temperature Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Thermonuclease Authors: Harms, M.J, Schlessman, J.L, Garcia-Moreno, E.B. Deposit date: 2008-05-15 Release date: 2009-01-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Arginine residues at internal positions in a protein are always charged. Proc.Natl.Acad.Sci.USA, 108, 2011
7N47	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 Descriptor: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-06-03 Release date: 2022-06-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7N55	The crystal structure of the mutant I38T PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 Descriptor: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-06-04 Release date: 2022-06-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7N8F	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 Descriptor: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-06-14 Release date: 2022-06-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6EUV	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787) Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2 Authors: Cusack, S, Lethier, M. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
5M72	Structure of the human SRP68-72 protein-binding domain complex Descriptor: GLYCEROL, POTASSIUM ION, SULFATE ION, ... Authors: Becker, M.M.M, Wild, K, Sinning, I. Deposit date: 2016-10-26 Release date: 2016-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res., 45, 2017
6EUY	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION Authors: Cusack, S, Gaudon, S. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EUW	Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2 Authors: Cusack, S, Gaudon, S. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
7B9C	Structure of a minimal SF3B core in complex with spliceostatin A (form I) Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... Authors: Cretu, C, Pena, V. Deposit date: 2020-12-14 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7B92	Structure of a minimal SF3B core in complex with sudemycin D6 (form II) Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... Authors: Cretu, C, Pena, V. Deposit date: 2020-12-14 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7B91	Structure of a minimal SF3B core in complex with pladienolide D (form I) Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... Authors: Cretu, C, Pena, V. Deposit date: 2020-12-13 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
7LM4	The crystal structure of the I38T mutant PA Endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. Deposit date: 2021-02-05 Release date: 2022-02-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
1H8A	CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3 Descriptor: CAAT/ENHANCER BINDING PROTEIN BETA, DNA(5'-(*CP*CP*AP*GP*TP*CP*CP*GP*TP*TP*AP* AP*GP*GP*AP*TP*TP*GP*CP*GP*CP*CP*AP*CP*AP*T)-3'), DNA(5'-(*GP*AP*TP*GP*TP*GP*GP*CP*GP*CP*AP* AP*TP*CP*CP*TP*TP*AP*AP*CP*GP*GP*AP*CP*TP*G)-3'), ... Authors: Tahirov, T.H, Ogata, K. Deposit date: 2001-01-31 Release date: 2002-01-28 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Mechanism of C-Myb-C/Ebpbeta Cooperation from Separated Sites on a Promoter Cell(Cambridge,Mass.), 108, 2002
4H3K	Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA polymerase II CTD peptide phosphorylated at Ser-2, Ser-5 and Ser-7 Descriptor: Hexapeptide, PHOSPHATE ION, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, ... Authors: Xiang, K, Tong, L. Deposit date: 2012-09-13 Release date: 2012-10-31 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev., 26, 2012
6S6B	Type III-B Cmr-beta Cryo-EM structure of the Apo state Descriptor: CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... Authors: Sofos, N, Montoya, G, Stella, S. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2020-09-16 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
6L94	The structure of the dioxygenase ABH1 from mouse Descriptor: FE (II) ION, Nucleic acid dioxygenase ALKBH1 Authors: Xie, W, Wang, C, Li, H, Zhang, Y. Deposit date: 2019-11-08 Release date: 2020-11-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.10012341 Å) Cite: ALKBH1 promotes lung cancer by regulating m6A RNA demethylation. Biochem Pharmacol, 189, 2021
5HHG	Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 Authors: Smith, K.M, Forwood, J.K. Deposit date: 2016-01-11 Release date: 2016-05-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
5AOX	Human Alu RNA retrotransposition complex in the ribosome-stalling conformation Descriptor: ACETATE ION, ALU JO CONSENSUS RNA, DI(HYDROXYETHYL)ETHER, ... Authors: Ahl, V, Weichenrieder, O. Deposit date: 2015-09-12 Release date: 2015-11-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Retrotransposition and Crystal Structure of an Alu Rnp in the Ribosome-Stalling Conformation. Mol.Cell, 60, 2015
6JOO	Crystal structure of Corynebacterium diphtheriae Cas9 in complex with sgRNA and target DNA Descriptor: 1,2-ETHANEDIOL, CRISPR-associated protein,CRISPR-associated endonuclease Cas9, Guide RNA, ... Authors: Hirano, S, Ishitani, R, Nishimasu, H, Nureki, O. Deposit date: 2019-03-22 Release date: 2019-04-17 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9. Nat Commun, 10, 2019
7MTY	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569 Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-05-13 Release date: 2022-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
5YU7	CRYSTAL STRUCTURE OF EXPORTIN-5 Descriptor: Exportin-5 Authors: Yamazawa, R, Jiko, C, Lee, S.J, Yamashita, E. Deposit date: 2017-11-20 Release date: 2018-08-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.301 Å) Cite: Structural Basis for Selective Binding of Export Cargoes by Exportin-5 Structure, 26, 2018

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