PDB: 10243 resultsInfo pagesStatus searchChemie searchBIRD

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6UTY	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Old" crystal soaked with CTP for 30 minutes) Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.15 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6FLQ	CryoEM structure of E.coli RNA polymerase paused elongation complex bound to NusA Descriptor: DNA (31-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Guo, X, Weixlbaumer, A. Deposit date: 2018-01-26 Release date: 2018-03-21 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural Basis for NusA Stabilized Transcriptional Pausing. Mol. Cell, 69, 2018
6UTX	E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.05 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UUB	E. coli sigma-S transcription initiation complex with a mismatching UTP ("Fresh" crystal soaked with UTP for 2 hours) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.955 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UUA	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Fresh" crystal soaked with CTP for 2 hours) Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.002 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
5TBZ	E. Coli RNA Polymerase complexed with NusG Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Steitz, T.A. Deposit date: 2016-09-13 Release date: 2016-12-07 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (7 Å) Cite: Structural insights into NusG regulating transcription elongation. Nucleic Acids Res., 45, 2017
6JCY	Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF sigma factor sigH/E Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
7EGQ	Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 10, ... Authors: Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2021-03-25 Release date: 2021-07-21 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
9BI9	GII.4 Sydney 2012 Polymerase domain of ProPol precursor Descriptor: MAGNESIUM ION, RNA-dependent RNA polymerase domain of Protease-Polymerase precursor Authors: Eruera, A, Krause, K. Deposit date: 2024-04-23 Release date: 2024-10-16 Last modified: 2025-04-30 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor. J.Virol., 98, 2024
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP Descriptor: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
7EIZ	Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 10, ... Authors: Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2021-04-01 Release date: 2021-09-22 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Cell, 184, 2021
7BEG	Structures of class I bacterial transcription complexes Descriptor: Class I pacrA promoter non-template DNA, Class I pacrA promoter template DNA, DNA-directed RNA polymerase subunit alpha, ... Authors: Ye, F.Z, Hao, M, Zhang, X.D. Deposit date: 2020-12-23 Release date: 2021-12-01 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
3K5M	Crystal structure of E.coli Pol II-abasic DNA-ddGTP Lt(-2, 2) ternary complex Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*TP*CP*CP*TP*GP*(3DR)P*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
5VSW	X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-05-12 Release date: 2017-06-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (4.295 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
5W1T	X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
7X6V	lymphocytic choriomeningitis virus polymerase- Matrix Z Protein Complex (LCMV L-Z Complex) Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... Authors: Liu, L, Lou, Z. Deposit date: 2022-03-08 Release date: 2023-09-13 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
5UI8	structure of sigmaN-holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Darst, S.A, Campbell, E.A. Deposit date: 2017-01-13 Release date: 2017-02-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.76 Å) Cite: Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5JS1	Human Argonaute2 Bound to an siRNA Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... Authors: Schirle, N.T, MacRae, I.J. Deposit date: 2016-05-07 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
2W69	Influenza polymerase fragment Descriptor: MANGANESE (II) ION, POLYMERASE ACIDIC PROTEIN, SULFATE ION Authors: Dias, A, Bouvier, D, Crepin, T, McCarthy, A.A, Hart, D.J, Baudin, F, Cusack, S, Ruigrok, R.W.H. Deposit date: 2008-12-17 Release date: 2009-02-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The CAP-Snatching Endonuclease of Influenza Virus Polymerase Resides in the Pa Subunit Nature, 458, 2009
4ZH3	Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.082 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4ZH4	Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 Descriptor: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.993 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
7CKM	Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... Authors: Xu, X, Peng, R, Peng, Q, Shi, Y. Deposit date: 2020-07-17 Release date: 2021-05-05 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
7CKL	Structure of Lassa virus polymerase bound to Z matrix protein Descriptor: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... Authors: Xu, X, Peng, R, Peng, Q, Shi, Y. Deposit date: 2020-07-17 Release date: 2021-05-05 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
4ZH2	Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.204 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
9F2R	Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site Descriptor: 3' end of the promoter vRNA, 5' end of the promoter vRNA, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Cusack, S, Drncova, P. Deposit date: 2024-04-23 Release date: 2024-09-18 Method: X-RAY DIFFRACTION (1.959 Å) Cite: High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit To Be Published

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