PDB: 1811 resultsInfo pagesStatus searchChemie searchBIRD

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4OH5	Crystal structure of T877A-AR-LBD bound with co-regulator peptide Descriptor: Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-17 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OHA	Crystal structure of T877A-AR-LBD bound with co-regulator peptide Descriptor: Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-17 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OJ9	Crystal structure of T877A-AR-LBD bound with co-regulator peptide Descriptor: Androgen receptor, GLYCEROL, HYDROXYFLUTAMIDE, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-20 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OGH	Crystal structure of T877A-AR-LBD Descriptor: Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-16 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4ONI	Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, GLYCEROL, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ... Authors: Gorman, M.A, Parker, M.W, Kusumo, S. Deposit date: 2014-01-28 Release date: 2015-02-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Human nuclear receptor LRH1 bound to phosopholipids and SHP peptide To be Published
4OEY	Crystal structure of AR-LBD bound with co-regulator peptide Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-14 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OH6	Crystal structure of T877A-AR-LBD bound with co-regulator peptide Descriptor: Androgen receptor, HYDROXYFLUTAMIDE, Protein BUD31 homolog, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-17 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.56 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OKB	Crystal structure of W741L-AR-LBD bound with co-regulator peptide Descriptor: Androgen receptor, Protein BUD31 homolog, R-BICALUTAMIDE, ... Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-22 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4P6X	Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain Descriptor: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Glucocorticoid receptor, Nuclear receptor coactivator 2 Authors: He, Y, Zhou, X.E, Tolbert, W.D, Powell, K, Melcher, K, Xu, H.E. Deposit date: 2014-03-25 Release date: 2014-04-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures and mechanism for the design of highly potent glucocorticoids. Cell Res., 24, 2014
4P6W	Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain Descriptor: Glucocorticoid receptor, MOMETASONE FUROATE, Nuclear receptor coactivator 2 Authors: He, Y, Zhou, X.E, Tolbert, W.D, Powell, K, Melcher, K, Xu, H.E. Deposit date: 2014-03-25 Release date: 2014-04-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Structures and mechanism for the design of highly potent glucocorticoids. Cell Res., 24, 2014
4PP6	Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Resveratrol Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, RESVERATROL Authors: Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Parent, A.A, Hughes, T.S, Pollock, J.A, Gjyshi, O, Cavett, V, Nowak, J, Garcia-Ordonez, R.D, Houtman, R, Griffin, P.R, Kojetin, D.J, Katzenellenbogen, J.A, Conkright, M.D, Nettles, K.W. Deposit date: 2014-02-26 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 3, 2014
4NB6	Crystal structure of the ligand binding domain of RORC with T0901317 Descriptor: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma Authors: Hymowitz, S.G, Boenig-de Leon, G. Deposit date: 2013-10-22 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23, 2013
4NIE	Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand Descriptor: 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... Authors: Ma, Y.L, Yang, L.Q. Deposit date: 2013-11-06 Release date: 2013-12-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 5, 2014
4OEA	Crystal structure of AR-LBD Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-12 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OFR	Crystal structure of AR-LBD bound with co-regulator peptide Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, co-regulator peptide Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-15 Release date: 2014-08-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OFU	Crystal structure of AR-LBD bound with co-regulator peptide Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, co-regulator peptide Authors: Liu, J.S, Hsu, C.L, Wu, W.G. Deposit date: 2014-01-15 Release date: 2014-08-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4N5G	Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 Descriptor: 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha Authors: Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. Deposit date: 2013-10-09 Release date: 2014-05-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
4N1Y	Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain Descriptor: Estrogen receptor Authors: Ortlund, E.O. Deposit date: 2013-10-04 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.605 Å) Cite: Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. PLoS Genet, 10, 2014
4PWL	Crystal structure of the complex between PPARgamma-LBD and the S enantiomer of Mbx-102 (Metaglidasen) Descriptor: (2S)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid, Peroxisome proliferator-activated receptor gamma Authors: Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Lavecchia, A, Piemontese, L. Deposit date: 2014-03-20 Release date: 2015-02-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles. Chemmedchem, 10, 2015
4Q13	Apo Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant with a glucocorticoid receptor-interacting protein 1 NR box II peptide Descriptor: Estrogen receptor, Glucocorticoid receptor-interacting protein 1 NR box II peptide Authors: Fanning, S.W, Panchamukhi, S, Greene, G.L. Deposit date: 2014-04-02 Release date: 2015-04-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. Elife, 5, 2016
4Q0A	Vitamin D Receptor complex with lithocholic acid Descriptor: (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Nuclear receptor coactivator 2, Vitamin D3 receptor A Authors: Belorusova, A, Rochel, N. Deposit date: 2014-04-01 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights into the molecular mechanism of vitamin d receptor activation by lithocholic Acid involving a new mode of ligand recognition. J.Med.Chem., 57, 2014
4PRG	0072 PARTIAL AGONIST PPAR GAMMA COCRYSTAL Descriptor: (+/-)(2S,5S)-3-(4-(4-CARBOXYPHENYL)BUTYL)-2-HEPTYL-4-OXO-5-THIAZOLIDINE, PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA) Authors: Milburn, M.V. Deposit date: 1999-05-07 Release date: 1999-05-27 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc.Natl.Acad.Sci.USA, 96, 1999
4PF3	Mineralocorticoid receptor ligand-binding domain with compuond 37a Descriptor: 1,2-ETHANEDIOL, 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one, Mineralocorticoid receptor Authors: Sogabe, S, Habuka, N. Deposit date: 2014-04-28 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists Bioorg.Med.Chem., 22, 2014
4N73	Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX Descriptor: Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING CO Authors: Matta-Camacho, E, Kojetin, D. Deposit date: 2013-10-14 Release date: 2014-06-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8662 Å) Cite: Structure of REV-ERB beta Ligand-binding Domain Bound to a Porphyrin Antagonist. J.Biol.Chem., 289, 2014
4PXM	The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide Descriptor: ESTRADIOL, Estrogen receptor, Nuclear receptor coactivator 2 Authors: Fanning, S.W, Panchamukhi, S, Greene, G.L. Deposit date: 2014-03-24 Release date: 2015-04-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. Elife, 5, 2016

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